Korean J Urol.  2012 Jun;53(6):405-409.

A Predictive Factor in Overactive Bladder Symptoms Improvement after Combined Anterior Vaginal Wall Prolapse Repair: A Pilot Study

Affiliations
  • 1Department of Urology, KEPCO Medical Foundation, Hanil General Hospital, Seoul, Korea. urohee@hanmail.net

Abstract

PURPOSE
We aimed to determine whether a preoperative urodynamic parameter is a valuable predictor for the persistence of OAB symptoms after the AVP repair.
MATERIALS AND METHODS
65 OAB patients with concomitant POP-Q stage III, IV anterior vaginal wall prolapse underwent a surgical repair were involved. All the patients were subjected to a preoperative urodynamic study, for whom the OABSS on questionnaire were preoperatively recorded. We firstly analyzed the correlation between the BOOI and the OABSS, then randomly divided patients into two groups: the group A (high PdetQmax, BOOI> or =20) and the group B (low PdetQmax, BOOI<20). In each group, the OABSS was repeatedly measured post-operatively and the change were analyzed.
RESULTS
31 patients were classified as the group A and 34 patients were classified as the group B. The group B showed significant decrease of symptom score in daytime frequency (p<0.01), urgency (p=0.04), urge incontinence (p=0.03), nocturnal frequency (p=0.01) and total score (p=0.01). The group A showed no significant decrease of symptom score in daytime frequency (p=0.42), urgency (p=0.61), urge incontinence (p=0.3), total score (p=0.15) except nocturnal frequency (p=0.01).
CONCLUSIONS
A preoperative pressure-flow study can be a valuable tool in predicting the OAB symptoms change after the combined AVP repair. While the AVP repair leads to the improvement of OAB symptoms generally, some patients with a higher preoperative PdetQmax are still in need of the additional medical treatment.

Keyword

Pelvic organ prolapse; Urinary bladder, overactive

MeSH Terms

Humans
Pelvic Organ Prolapse
Pilot Projects
Prolapse
Urinary Bladder, Overactive
Urinary Incontinence, Urge
Urodynamics

Figure

  • FIG. 1 Correlation between the BOOI and the total OABSS score before the AVP repair.

  • FIG. 2 Correlation between the BOOI and the Urgency score before the AVP repair.


Reference

1. de Boer TA, Cluivers KB, Withagen MI, Milani AL, Vierhout ME. Predictive factors for overactive bladder symptomsafter pelvic organ prolapse surgery. Int Urogynecol J. 2010; 21:1143–1149. PMID: 20419366.
2. Lawrence JM, Lukacz ES, Nager CW, Hsu JW, Luber KM. Prevalence and co-occurrence of pelvic floor disorders in community-dwelling women. Obstet Gynecol. 2008; 111:678–685. PMID: 18310371.
Article
3. Miedel A, Tegerstedt G, Maehle-Schmidt M, Nyrén O, Hammarström M. Symptoms and pelvic support defectsin specific compartments. Obstet Gynecol. 2008; 112:851–858. PMID: 18827128.
4. Digesu GA, Salvatore S, Chaliha C, Athanasious S, Milani R, Khullar V. Do overactive bladder symptoms improve after repair of anterior vaginal wall prolapse? Int Urogynecol J Pelvic Floor Dysfunct. 2007; 18:1439–1443. PMID: 17429557.
Article
5. Foster RT Sr, Barber MD, Parasio MF, Walters MD, Wekdner AC, Amundsen CL. A prospective assessment of overactive bladder symptoms in a cohort of elderly women who underwent transvaginal surgery for advanced pelvic organ prolapse. Am J Obstet Gynecol. 2007; 197:82.e1–82.e4. PMID: 17618768.
Article
6. Stanton SL, Hilton P, Norton C, Cardozo L. Clinical and urodynamic effects of anterior colporrhaphy and vaginal hysterectomy for prolapse with and without incontinence. Br J Obstet Gynaecol. 1982; 89:459–463. PMID: 7082603.
Article
7. Clemons JL, Aguilar VC, Tillinghast TA, Jackson ND, Myers DL. Patient satisfaction and changes in prolapse and urinary symptoms in women who were fitted successfully with a pessary for pelvic organ prolapse. Am J Obstet Gynecol. 2004; 190:1025–1029. PMID: 15118635.
Article
8. Fernando RJ, Thakar R, Sultan AH, Shah SM, Jones PW. Effect of vaginal pessaries on symptoms associated with pelvic organ prolapse. Obstet Gynecol. 2006; 108:93–99. PMID: 16816061.
Article
9. Hanson LA, Schulz JA, Flood CG, Cooley B, Tam F. Vaginal pessaries in managing women with pelvic organ prolapse and urinary incontinence: patient characteristics and factors contributing to success. Int Urogynecol J Pelvic Floor Dysfunct. 2006; 17:155–159. PMID: 16044204.
Article
10. Fletcher SG, Haverkorn RM, Yan J, Lee JJ, Zimmern PE, Lemack GE. Demographic and urodynamic factors associated with persistent OAB after anterior compartment prolapse repair. Neurourol Urodyn. 2010; 29:1414–1418. PMID: 20623545.
Article
11. Homma Y, Yoshida M, Seki N, Yokoyama O, Kakizaki H, Gotoh M, et al. Symptom assessment tool for overactive bladder syndrome-overactive bladder symptom score. Urology. 2006; 68:318–323. PMID: 16904444.
Article
12. Gosling JA, Gilpin SA, Dixon JS, Gilpin CJ. Decrease in the autonomic innervations of human detrusor muscle in outflow obstruction. J Urol. 1986; 136:501–504. PMID: 3735523.
13. Harrison SC, Hunnam GR, Farman P, Ferguson DR, Doyle PT. Bladder instability and denervation in patients with bladder outflow obstruction. Br J Urol. 1987; 60:519–522. PMID: 3427336.
Article
14. Harrison SC, Ferguson DR, Doyle PT. Effect of bladder outflow obstruction on the innervation of the rabbit urinary bladder. Br J Urol. 1990; 66:372–379. PMID: 1699626.
Article
15. Sibley GN. The physiological response of the detrusor muscle to experimental bladder outflow obstruction in the pig. Br J Urol. 1987; 60:332–336. PMID: 3690205.
Article
16. Azadzoi KM, Pontari M, Vlachiotis J, Siroky MB. Canine bladder blood flow andoxygenation: changes induced by filling, contraction and outlet obstruction. J Urol. 1996; 155:1459–1465. PMID: 8632611.
17. de Boer TA, Salvatore S, Cardozo L, Chapple C, Kelleher C, van Kerrebroeck P, et al. Pelvic organ prolapse and overactive bladder. Neurourol Urodyn. 2010; 29:30–39. PMID: 20025017.
Article
18. Seki N, Karim OM, Mostwin JL. The effect of experimental urethral obstruction and its reversal on changes in passive electrical properties of detrusor muscle. J Urol. 1992; 148:1957–1961. PMID: 1331551.
Article
19. Steers WD, de Groat WC. Effect of bladder outlet obstruction on micturition reflex pathways in the rat. J Urol. 1988; 140:864–871. PMID: 3418824.
Article
20. Steers WD, Kolbeck S, Creedon D, Tuttle JB. Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest. 1991; 88:1709–1715. PMID: 1939656.
Article
21. Steers WD, Ciambotti J, Etzel B, Erdman S, de Groat WC. Alterations in afferent pathways from the urinary bladder of the rat in response to partial urethral obstruction. J Comp Neurol. 1991; 310:401–410. PMID: 1723990.
Article
22. Ferguson DR, Kennedy I, Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes-a possible sensory mechanism? J Physiol. 1997; 505:503–511. PMID: 9423189.
23. Sun Y, Chai TC. Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis. J Urol. 2004; 171:448–452. PMID: 14665953.
24. Yoshida M, Inadome A, Maeda Y, Satoji Y, Masunaga K, Sugiyama Y, et al. Non-neuronal cholinergic system in human bladder urothelium. Urology. 2006; 67:425–430. PMID: 16461116.
Article
25. Yuan Z, Shen H. Pelvic organ prolapse quantification in women referred with overactive bladder. Int Urogynecol J. 2010; 21:1365–1369. PMID: 20577715.
Article
26. Klutke JJ, Ramos S. Urodynamic outcome after surgery for severe prolapse and potential stress incontinence. Am J Obstet Gynecol. 2000; 182:1378–1381. PMID: 10871452.
Article
27. Araki I, Haneda Y, Mikami Y, Takeda M. Incontinence and detrusor dysfunction associated with pelvic organ prolapse: clinical value of preoperative urodynamic evaluation. Int Urogynecol J Pelvic Floor Dysfunct. 2009; 20:1301–1306. PMID: 19597715.
Article
28. Nguyen JK, Bhatia NN. Resolution of motor urge incontinence after surgical repair of pelvic organ prolapse. J Urol. 2001; 166:2263–2266. PMID: 11696748.
Article
29. Lee CJ, Cho MC, Ku JH, Kim SW, Paick JS. Changes in nocturia after photoselective vaporization ofthe prostate for patients with benign prostatic hyperplasia. Korean J Urol. 2010; 51:531–536. PMID: 20733958.
Full Text Links
  • KJU
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr