Pediatr Allergy Respir Dis.
2010 Dec;20(4):284-291.
The Relationship between Early Changes in Respiratory Parameters and the Prognosis in Children with Acute Lung Injury
- Affiliations
-
- 1Department of Pediatrics, Asan Medical Center Children's hospital, University of Ulsan College of Medicine, Seoul, Korea. drpsj@amc.seoul.kr
- 2Department of Pediatrics, Chungju Hospital, University of Konkuk College of Medicine, Chunju, Korea.
Abstract
- PURPOSE
The PaO2/FiO2 (P/F) ratio, oxygenation index (OI) and the ventilation index (VI) have been used as parameters of acute respiratory failure. This study was conducted to evaluate the relationship between the prognosis and early changes in the respiratory parameters in pediatric patients with acute lung injury (ALI).
METHODS
This is a retrospective study of 97 patients who had ventilator care for more than 3 days due to acute respiratory failure between January 2008 and May 2009 in PICU of Asan Medical Center.
RESULTS
The mean age was 3.7+/-5.0 years. This study included 58 males and 39 females. The mortality rate was 27.8%. There was no significant difference between the survivors and non-survivors in the initial P/F ratio, OI and VI. However, these parameters improved in the survivor group, unlike the non-survivor group whose parameters remained unchanged or worsened. When comparing the receiver operating characteristic (ROC) curve of the initial respiratory parameters and the changes in parameters for 3 days, the area under the ROC curves representing the changes in respiratory parameters for 3 days was significantly greater than that of initial respiratory parameters, thus indicating the parameter changes are more reliable predictors of mortality than the initial parameters.
CONCLUSION
Early changes in respiratory parameters such as the P/F ratio, OI and VI, rather than initial parameters themselves, are more directly related to the prognosis of pediatric patients with ALI and would be useful in determining optimal treatment and predicting the prognosis.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effect of Recruiting Maneuvers in a Patient with Acute Lung Injury after Femoral Nailing: A case report
- Ventilator-Induced Lung Injury
- Nonventilatory medical treatments for acute respiratory distress syndrome and acute lung injury
- Cause and Prognosis of Pediatric Acute Respiratory Failure by Intrapulmonary Lesion
- Antithrombin-III as an early prognostic factor in children with acute lung injury
