Pediatr Allergy Respir Dis.
2009 Jun;19(2):146-154.
Allergen Sensitization of Severe Atopic Dermatitis in Children under 2 Years
- Affiliations
-
- 1Department of Pediatrics, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Korea.
- 2Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Korea.
- 3Department of Pediatrics, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Gyeonggido, Korea. imipenem@hanmail.net
Abstract
- PURPOSE
Atopic dermatitis (AD) is the allergic disease which appears during infancy. This study aimed to find associations between clinical parameters, allergen sensitization and severity of AD in chidren under 2 years.
METHODS
Two hundred fifteen patients (123 boys, 92 girls) under 2 years with severe AD who visited the department of pediatrics of Hangang Sacred Heart Hospital and Asan Medical Center were enrolled. We checked the severity scoring of atopic dermatitis (SCORAD), total eosinophil count, eosinophil ratio, eosionphil cationic protein (ECP), total IgE and specific IgE to 12 allergens [egg white, milk, soybean, peanut, wheat, fish, Dermatophagoides pteronyssinus (D.p), Dermatophagoides farinae (D.f), dog, cat, cockroach, alternaria]. Atopic AD was defined as serum total IgE 200 IU/mL or specific IgE positive.
RESULTS
The mean of SCORAD was 69.0. Atopic AD was 161 (75%). There were no differences in age between atopic and non-atopic AD. However, SCORAD, IgE, eosinophil, and ECP were the higher in atopic AD. Sensitization to food allergen was the highest in egg white (76.4%), followed by milk (58.4%) and aeroallergens such as D.f (49.1%) and D.p (46.6%). The more the number of sensitized food allergens, the higher the SCORAD appeared. However, it did not show any relationships with the number of sensitized aeroallergens.
CONCLUSION
The percentage and severity were higher in atopic AD than non-atopic AD. The number of sensitized to food allergen affect the severity. Therefore, understanding the sensitization to food allergens may be more helpful in predicting severity than sensitization to aeroallergen. In cases of positive reaction to aeroallergens, it is necessary to observe the development of respiratory allergic disease.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Relationship between Allergen Sensitization and Frequency of Asthma in Preschool Atopic Dermatitis Children
- The Effect of Antigen Sensitization and Development of Respiratory Allergy Disease on Severity of Atopic Dermatitis
- Positive conversion of specific IgE against house dust mite in children with atopic dermatitis under 24 months of age
- Clinical Investigation of Children with Severe Atopic Dermatitis
- Allergen sensitization and clinical characteristics in young children with atopic dermatitis
