Korean J Urol.  2010 Jan;51(1):1-7.

Cell-Based Therapy for Urinary Incontinence

Affiliations
  • 1Department of Urology and Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. jyoo@wfubmc.edu
  • 2Joint Institute for Regenerative Medicine, Kyungpook National University Hospital, Daegu, Korea.
  • 3Department of Urology, Korea University Medical Center, Seoul, Korea.

Abstract

Urinary incontinence has become a societal problem that affects millions of people worldwide. Although numerous therapeutic modalities are available, none has been shown to be entirely satisfactory. Consequently, cell-based approaches using regenerative medicine technology have emerged as a potential solution that would provide a means of correcting anatomical deficiencies and restoring normal function. As such, numerous cell-based investigations have been performed to develop systems that are focused on addressing clinical needs. While most of these attempts remain in the experimental stages, several clinical trials are being designed or are in progress. This article provides an overview of the cell-based approaches that utilize various cell sources to develop effective treatment modalities for urinary incontinence.

Keyword

Cell therapy; Regenerative medicine; Urinary incontinence

MeSH Terms

Regenerative Medicine
Tissue Therapy
Urinary Incontinence

Reference

1. Hannestad YS, Rortveit G, Sandvik H, Hunskaar S. A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT study. Epidemiology of Incontinence in the County of Nord-Trondelag. J Clin Epidemiol. 2000; 53:1150–1157. PMID: 11106889.
2. Malmsten UG, Milsom I, Molander U, Norlen LJ. Urinary incontinence and lower urinary tract symptoms: an epidemiological study of men aged 45 to 99 years. J Urol. 1997; 158:1733–1737. PMID: 9334589.
Article
3. Dalpiaz O, Curti P. Role of perineal ultrasound in the evaluation of urinary stress incontinence and pelvic organ prolapse: a systematic review. Neurourol Urodyn. 2006; 25:301–306. PMID: 16688711.
Article
4. Walsh LP, Zimmern PE, Pope N, Shariat SF. Comparison of the Q-tip test and voiding cystourethrogram to assess urethral hypermobility among women enrolled in a randomized clinical trial of surgery for stress urinary incontinence. J Urol. 2006; 176:646–649. PMID: 16813912.
Article
5. Alhasso A, Glazener CM, Pickard R, N'Dow J. Adrenergic drugs for urinary incontinence in adults. Cochrane Database Syst Rev. 2003; 2:CD001842. PMID: 12804414.
Article
6. Bo K, Talseth T, Holme I. Single blind, randomised controlled trial of pelvic floor exercises, electrical stimulation, vaginal cones, and no treatment in management of genuine stress incontinence in women. BMJ. 1999; 318:487–493. PMID: 10024253.
Article
7. Burns PA, Pranikoff K, Nochajski TH, Hadley EC, Levy KJ, Ory MG. A comparison of effectiveness of biofeedback and pelvic muscle exercise treatment of stress incontinence in older community-dwelling women. J Gerontol. 1993; 48:M167–M174. PMID: 8315230.
8. Glazener CM, Herbison GP, MacArthur C, Grant A, Wilson PD. Randomised controlled trial of conservative management of postnatal urinary and faecal incontinence: six year follow up. BMJ. 2005; 330:337. PMID: 15615766.
Article
9. Goode PS, Burgio KL, Locher JL, Roth DL, Umlauf MG, Richter HE, et al. Effect of behavioral training with or without pelvic floor electrical stimulation on stress incontinence in women: a randomized controlled trial. JAMA. 2003; 290:345–352. PMID: 12865375.
10. Sharifi-Aghdas F. Surgical management of stress urinary incontinence. Urol J. 2005; 2:175–182. PMID: 17602425.
11. Kiilholma P, Mäkinen J, Chancellor MB, Pitkänen Y, Hirvonen T. Modified Burch colposuspension for stress urinary incontinence in females. Surg Gynecol Obstet. 1993; 176:111–115. PMID: 8421796.
12. Nilsson CG, Kuuva N, Falconer C, Rezapour M, Ulmsten U. Long-term results of the tension-free vaginal tape (TVT) procedure for surgical treatment of female stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2001; 12(Suppl 2):S5–S8. PMID: 11450979.
Article
13. Ulmsten U, Falconer C, Johnson P, Jomaa M, Lanner L, Nilsson CG, et al. A multicenter study of tension-free vaginal tape (TVT) for surgical treatment of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 1998; 9:210–213. PMID: 9795826.
Article
14. Herschorn S, Steele DJ, Radomski SB. Followup of intraurethral collagen for female stress urinary incontinence. J Urol. 1996; 156:1305–1309. PMID: 8808860.
Article
15. Corcos J, Fournier C. Periurethral collagen injection for the treatment of female stress urinary incontinence: 4-year follow-up results. Urology. 1999; 54:815–818. PMID: 10565739.
Article
16. Smaldone MC, Chancellor MB. Muscle derived stem cell therapy for stress urinary incontinence. World J Urol. 2008; 26:327–332. PMID: 18470515.
Article
17. Atala A. Tissue engineering and regenerative medicine: concepts for clinical application. Rejuvenation Res. 2004; 7:15–31. PMID: 15256042.
Article
18. Atala A. Recent developments in tissue engineering and regenerative medicine. Curr Opin Pediatr. 2006; 18:167–171. PMID: 16601497.
Article
19. Koh CJ, Atala A. Tissue engineering, stem cells, and cloning: opportunities for regenerative medicine. J Am Soc Nephrol. 2004; 15:1113–1125. PMID: 15100351.
Article
20. Kuhn A, Gelman W, Kuhn P. Injectable therapy for urinary incontinence: a review. Praxis. 2004; 93:188–192. PMID: 15008014.
21. Cilento BG, Freeman MR, Schneck FX, Retik AB, Atala A. Phenotypic and cytogenetic characterization of human bladder urothelia expanded in vitro. J Urol. 1994; 152:665–670. PMID: 7517459.
Article
22. Scriven SD, Booth C, Thomas DF, Trejdosiewicz LK, Southgate J. Reconstitution of human urothelium from monolayer cultures. J Urol. 1997; 158:1147–1152. PMID: 9258159.
Article
23. Liebert M, Hubbel A, Chung M, Wedemeyer G, Lomax MI, Hegeman A, et al. Expression of mal is associated with urothelial differentiation in vitro: identification by differential display reverse-transcriptase polymerase chain reaction. Differentiation. 1997; 61:177–185. PMID: 9084136.
Article
24. Puthenveettil JA, Burger MS, Reznikoff CA. Replicative senescence in human uroepithelial cells. Adv Exp Med Biol. 1999; 462:83–91. PMID: 10599415.
Article
25. Cilento BG, Freeman MR, Schneck FX, Retik AB, Atala A. Phenotypic and cytogenetic characterization of human bladder urothelia expanded in vitro. J Urol. 1994; 152:665–670. PMID: 7517459.
Article
26. Freeman MR, Yoo JJ, Raab G, Soker S, Adam RM, Schneck FX, et al. Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder. J Clin Invest. 1997; 99:1028–1036. PMID: 9062361.
Article
27. Liebert M, Wedemeyer G, Abruzzo LV, Kunkel SL, Hammerberg C, Cooper KD, et al. Stimulated urothelial cells produce cytokines and express an activated cell surface antigenic phenotype. Semin Urol. 1991; 9:124–130. PMID: 1853009.
28. Nguyen HT, Park JM, Peters CA, Adam RM, Orsola A, Atala A, et al. Cell-specific activation of the HB-EGF and ErbB1 genes by stretch in primary human bladder cells. In Vitro Cell Dev Biol Anim. 1999; 35:371–375. PMID: 10462199.
Article
29. Oberpenning F, Meng J, Yoo JJ, Atala A. De novo reconstitution of a functional mammalian urinary bladder by tissue engineering. Nat Biotechnol. 1999; 17:149–155. PMID: 10052350.
Article
30. Puthenveettil JA, Burger MS, Reznikoff CA. Replicative senescence in human uroepithelial cells. Adv Exp Med Biol. 1999; 462:83–91. PMID: 10599415.
Article
31. Kim BS, Mooney DJ. Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol. 1998; 16:224–230. PMID: 9621462.
Article
32. Bent AE, Tutrone RT, McLennan MT, Lloyd LK, Kennelly MJ, Badlani G. Treatment of intrinsic sphincter deficiency using autologous ear chondrocytes as a bulking agent. Neurourol Urodyn. 2001; 20:157–165. PMID: 11170190.
Article
33. Noth U, Tuli R, Osyczka AM, Danielson KG, Tuan RS. In vitro engineered cartilage constructs produced by press-coating biodegradable polymer with human mesenchymal stem cells. Tissue Eng. 2002; 8:131–144. PMID: 11886661.
34. Wang Y, Blasioli DJ, Kim HJ, Kim HS, Kaplan DL. Cartilage tissue engineering with silk scaffolds and human articular chondrocytes. Biomaterials. 2006; 27:4434–4442. PMID: 16677707.
Article
35. Keegan PE, Atiemo K, Cody J, McClinton S, Pickard R. Periurethral injection therapy for urinary incontinence in women. Cochrane Database Syst Rev. 2007; 3:CD003881. PMID: 17636740.
Article
36. Trabucco E, Soderberg M, Cobellis L, Torella M, Bystrom B, Ekman-Ordeberg G, et al. Role of proteoglycans in the organization of periurethral connective tissue in women with stress urinary incontinence. Maturitas. 2007; 58:395–405. PMID: 18022774.
Article
37. Isom-Batz G, Zimmern PE. Collagen injection for female urinary incontinence after urethral or periurethral surgery. J Urol. 2009; 181:701–704. PMID: 19091340.
Article
38. Folkman J, Hochberg M. Self-regulation of growth in three dimensions. J Exp Med. 1973; 138:745–753. PMID: 4744009.
Article
39. Khademhosseini A, Langer R, Borenstein J, Vacanti JP. Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci U S A. 2006; 103:2480–2487. PMID: 16477028.
Article
40. Atala A, Bauer SB, Soker S, Yoo JJ, Retik AB. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006; 367:1241–1246. PMID: 16631879.
Article
41. Ahrendt G, Chickering DE, Pranieri JP. Angiogenic growth factors: a review for tissue engineering. Tissue Eng. 1998; 4:117–130.
Article
42. De Coppi P, Delo D, Farrugia L, Udompanyanan K, Yoo JJ, Nomi M, et al. Angiogenic gene-modified muscle cells for enhancement of tissue formation. Tissue Eng. 2005; 11:1034–1044. PMID: 16144439.
43. Smith MK, Peters MC, Richardson TP, Garbern JC, Mooney DJ. Locally enhanced angiogenesis promotes transplanted cell survival. Tissue Eng. 2004; 10:63–71. PMID: 15009931.
Article
44. Tilkorn D, Messina A, Bedogni A, Keramidaris E, Han X, Palmer J, et al. Implanted myoblast survival is dependent on the degree of vascularization in a novel delayed implantation/prevascularization tissue engineering model. Tissue Eng Part A. 2009.
Article
45. Seach N, Mattesich M, Abberton K, Matsuda K, Tilkorn DJ, Rophael J, et al. Vascularized tissue engineering mouse chamber model supports thymopoiesis of ectopic thymus tissue grafts. Tissue Eng Part C Methods. 2009; Epub ahead of print.
Article
46. Harrison BS, Eberli D, Lee SJ, Atala A, Yoo JJ. Oxygen generating biomaterials for tissue regeneration. Biomaterials. 2007; 28:4628–4634. PMID: 17681597.
47. Oh SH, Ward CL, Atala A, Yoo JJ, Harrison BS. Oxygen generating scaffolds for enhancing engineered tissue survival. Biomaterials. 2009; 30:757–762. PMID: 19019425.
Article
48. Atala A, Kim W, Paige KT, Vacanti CA, Retik AB. Endoscopic treatment of vesicoureteral reflux with a chondrocyte-alginate suspension. J Urol. 1994; 152:641–643. PMID: 8021988.
Article
49. Diamond DA, Caldamone AA. Endoscopic correction of vesicoureteral reflux in children using autologous chondrocytes: preliminary results. J Urol. 1999; 162:1185–1188. PMID: 10458462.
Article
50. Yokoyama T, Huard J, Chancellor MB. Myoblast therapy for stress urinary incontinence and bladder dysfunction. World J Urol. 2000; 18:56–61. PMID: 10766045.
Article
51. Chancellor MB, Yokoyama T, Tirney S, Mattes CE, Ozawa H, Yoshimura N, et al. Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor contractility. Neurourol Urodyn. 2000; 19:279–287. PMID: 10797585.
Article
52. Strasser H, Berjukow S, Marksteiner R, Margreiter E, Hering S, Bartsch G, et al. Stem cell therapy for urinary stress incontinence. Exp Gerontol. 2004; 39:1259–1265. PMID: 15489048.
Article
53. Collins CA, Olsen I, Zammit PS, Heslop L, Petrie A, Partridge TA, et al. Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell. 2005; 122:289–301. PMID: 16051152.
Article
54. Smythe GM, Grounds MD. Exposure to tissue culture conditions can adversely affect myoblast behavior in vivo in whole muscle grafts: implications for myoblast transfer therapy. Cell Transplant. 2000; 9:379–393. PMID: 10972337.
Article
55. Yiou R, Lefaucheur JP, Atala A. The regeneration process of the striated urethral sphincter involves activation of intrinsic satellite cells. Anat Embryol. 2003; 206:429–435. PMID: 12728313.
Article
56. Yiou R, Yoo JJ, Atala A. Restoration of functional motor units in a rat model of sphincter injury by muscle precursor cell autografts. Transplantation. 2003; 76:1053–1060. PMID: 14557752.
57. Lecoeur C, Swieb S, Zini L, Riviere C, Combrisson H, Gherardi R, et al. Intraurethral transfer of satellite cells by myofiber implants results in the formation of innervated myotubes exerting tonic contractions. J Urol. 2007; 178:332–337. PMID: 17507041.
Article
58. Jankowski RJ, Deasy BM, Huard J. Muscle-derived stem cells. Gene Ther. 2002; 9:642–647. PMID: 12032710.
Article
59. Chancellor MB, Yokoyama T, Tirney S, Mattes CE, Ozawa H, Yoshimura N, et al. Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor contractility. Neurourol Urodyn. 2000; 19:279–287. PMID: 10797585.
Article
60. Yokoyama T, Huard J, Chancellor MB. Myoblast therapy for stress urinary incontinence and bladder dysfunction. World J Urol. 2000; 18:56–61. PMID: 10766045.
Article
61. Bonavaud S, Agbulut O, D'Honneur G, Nizard R, Mouly V, Butler-Browne G. Preparation of isolated human muscle fibers: a technical report. in vitro Cell Dev Biol Anim. 2002; 38:66–72. PMID: 11928997.
Article
62. Eberli D, Soker S, Atala A, Yoo JJ. Optimization of human skeletal muscle precursor cell culture and myofiber formation in vitro. Methods. 2009; 47:98–103. PMID: 18952174.
Article
63. Strasser H, Marksteiner R, Margreiter E, Pinggera GM, Mitterberger M, Fritsch H, et al. Stem cell therapy for urinary incontinence. Urologe A. 2004; 43:1237–1241. PMID: 15549161.
64. Strasser H, Marksteiner R, Margreiter E, Pinggera GM, Mitterberger M, Frauscher F, et al. Autologous myoblasts and fibroblasts versus collagen for treatment of stress urinary incontinence in women: a randomised controlled trial. Lancet. 2007; 369:2179–2186. PMID: 17604800.
65. Kleinert S, Horton R. Retraction--autologous myoblasts and fibroblasts versus collagen [corrected] for treatment of stress urinary incontinence in women: a [corrected] randomised controlled trial. Lancet. 2008; 372:789–790. PMID: 18774408.
66. Feki A, Faltin DL, Lei T, Dubuisson JB, Jacob S, Irion O. Sphincter incontinence: is regenerative medicine the best alternative to restore urinary or anal sphincter function? Int J Biochem Cell Biol. 2007; 39:678–684. PMID: 17208507.
Article
67. Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev. 2005; 19:1129–1155. PMID: 15905405.
Article
68. Becker C, Jakse G. Stem cells for regeneration of urological structures. Eur Urol. 2007; 51:1217–1228. PMID: 17254699.
Article
69. Lewis JM, Cheng EY. Non-traditional management of the neurogenic bladder: tissue engineering and neuromodulation. ScientificWorldJournal. 2007; 7:1230–1241. PMID: 17704856.
Article
70. Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol. 2000; 18:399–404. PMID: 10748519.
Article
71. De Coppi P, Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007; 25:100–106. PMID: 17206138.
Article
72. De Coppi P, Callegari A, Chiavegato A, Gasparotto L, Piccoli M, Taiani J, et al. Amniotic fluid and bone marrow derived mesenchymal stem cells can be converted to smooth muscle cells in the cryo-injured rat bladder and prevent compensatory hypertrophy of surviving smooth muscle cells. J Urol. 2007; 177:369–376. PMID: 17162093.
Article
73. Atala A. Regenerative medicine and tissue engineering in urology. Urol Clin North Am. 2009; 36:199–209. PMID: 19406321.
Article
74. Baker SC, Rohman G, Southgate J, Cameron NR. The relationship between the mechanical properties and cell behaviour on PLGA and PCL scaffolds for bladder tissue engineering. Biomaterials. 2009; 30:1321–1328. PMID: 19091399.
Article
75. Fierabracci A, Caione P, Di Giovine M, Zavaglia D, Bottazzo GF. Identification and characterization of adult stem/progenitor cells in the human bladder (bladder spheroids): perspectives of application in pediatric surgery. Pediatr Surg Int. 2007; 23:837–839. PMID: 17619197.
Article
76. Lane TA, Ho AD, Bashey A, Peterson S, Young D, Law P. Mobilization of blood-derived stem and progenitor cells in normal subjects by granulocyte-macrophage- and granulocyte-colony-stimulating factors. Transfusion. 1999; 39:39–47. PMID: 9920165.
Article
77. Vrana KE, Hipp JD, Goss AM, McCool BA, Riddle DR, Walker SJ, et al. Nonhuman primate parthenogenetic stem cells. Proc Natl Acad Sci U S A. 2003; 100(Suppl 1):11911–11916. PMID: 14504386.
Article
78. Brazel CY, Ducceschi MH, Pytowski B, Levison SW. The FLT3 tyrosine kinase receptor inhibits neural stem/progenitor cell proliferation and collaborates with NGF to promote neuronal survival. Mol Cell Neurosci. 2001; 18:381–393. PMID: 11640895.
Article
79. Inanc B, Elcin AE, Elcin YM. Human embryonic stem cell differentiation on tissue engineering scaffolds: effects of NGF and retinoic acid induction. Tissue Eng Part A. 2008; 14:955–964. PMID: 19230122.
80. Nakajima M, Ishimuro T, Kato K, Ko IK, Hirata I, Arima Y, et al. Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation. Biomaterials. 2007; 28:1048–1060. PMID: 17081602.
Article
81. Jack GS, Almeida FG, Zhang R, Alfonso ZC, Zuk PA, Rodriguez LV. Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol. 2005; 174:2041–2045. PMID: 16217390.
Article
82. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7:211–228. PMID: 11304456.
Article
83. Lin G, Wang G, Banie L, Ning H, Shindel AW, Fandel TM, et al. Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Cytotherapy. 2009; Epub ahead of print.
Article
84. Drost AC, Weng S, Feil G, Schäfer J, Baumann S, Kanz L, et al. In vitro myogenic differentiation of human bone marrow-derived mesenchymal stem cells as a potential treatment for urethral sphincter muscle repair. Ann N Y Acad Sci. 2009; 1176:135–143. PMID: 19796241.
Article
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