Pediatr Allergy Respir Dis.
2004 Dec;14(4):384-391.
Comparison of Clinical Effect and Compliance according to Administration Route of beta2-agonist in Childhood Asthma
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Soonchunhyang University, Seoul, Korea. bypyun@hosp.sch.ac.kr
Abstract
- PURPOSE
This study was performed to evaluate the efficacy and compliance of beta2- agonist according to the type of preparations in the children with asthma. METHODS: Randomly selected 30 patients, who visited to Soonchunhyang University Hospital with acute asthma attack from May to August, 2004 were enrolled. Patients were randomly divided into 3 groups. We evaluated asthma symptom score before and 1 week after treatment in each group. Also, we measured O2 saturation, peak expiratory flow rate (PEFR), heart rate, and evaluated adverse reactions during the treatment. Treatment compliance was evaluated by the face to face interview with the patients and their guardians after 1 week of treatment. RESULTS: The mean asthma symptom score before and after treatment in each group were 5.9 and 1.1 in transdermal group, 5.4 and 0.9 in inhalation group, and 5.5 and 1.3 in oral group, respectively. Mean improvement of PEFR was 23.7% predicted after treatment. There was no serious adverse reactionin each group except mild itching of patch site in one case of transdermal group. Compliance of each group was relatively good. CONCLUSION: For the treatment of acute asthma attack, there was no difference in efficacy and safety of beta-agonist among the type of preparations. Also, there was no difference in adverse reaction and compliance between the type of preparation. Therefore it will be useful to choose the preparation with better compliance in each patient for the effective treatment of childhood asthma.
