Nucl Med Mol Imaging.  2006 Apr;40(2):106-112.

Radioisotope Treatment for Benign Strictures of Non-vascular Luminal Organs

• Shin JH

Abstract

Tissue hyperplasia is one of the most frequently encountered complications when self-expanding metallic stents are placed in benign non-vascular luminal organ strictures, thus causing restenosis of the lumen. The investigators postulated that ionizing irradiation could be applied to prevent restenosis caused by tissue hyperplasia in non-vascular luminal organs as it reduced coronary or peripheral arterial narrowing successfully. The authors combined beta-irradiation using 188Re-MAG3 solution with balloon dilation for animal and clinical studies because this new treatment approach had the advantages such as low penetration depth of beta-ray, self-centering irradiation, and mechanical effect of balloon dilation over using gamma-irradiation with afterloading devices. In this article, the concept and mechanism of radioisotope balloon dilation, and animal and clinical studies using radioisotope balloon dilation are reviewed.

Keyword

radioisotope application; stents and prostheses; balloon dilation

MeSH Terms

Animals
Constriction, Pathologic*
Humans
Hyperplasia
Phenobarbital*
Research Personnel
Stents
Phenobarbital