Lab Anim Res.  2012 Mar;28(1):67-69. 10.5625/lar.2012.28.1.67.

Adiaspiromycosis of an Apodemus agrarius captured wild rodent in Korea

• Kim TH
• Han JH
• Chang SN
• Kim DS
• Abdelkader TS
• Seok SH
• Park JH
• Oh HS
• Kim JT
• Lee BH
• Shin JH
• Kim JH
• Kim JM
• Park JH

• KMID: 2312095
• DOI: http://doi.org/10.5625/lar.2012.28.1.67

Abstract

Adiaspiromycosis is caused by pulmonary infection with Emmonsia. Inhalated spores of Emmonsia cause asymptomatic infection to necrogranulomatous pneumonia, depending on the burden of adiaspore and host immunity. For disease monitoring of wild rodents captured on Jeju Island in Korea, we examined the lung tissue of wild rodents histopathologically. Spores composed of thick three-layered walls were found following histopathological examination and were diagnosed as adiaspiromycosis. Adiaspiromycosis has been found in mammals in many parts of the world. To our knowledge, this is the first report of adiaspiromycosis of an Apodemus agrarius captured in Korea.

Keyword

Adiaspiromycosis; Emmonisia crescens; wild rodent

MeSH Terms

Animals
Asymptomatic Infections
Chrysosporium
Korea
Lung
Mammals
Murinae
Pneumonia
Rodentia
Spores

Figure

• 

  Figure 1 Adiaspores of Emmonsia sp. in the lung parenchyma of an Apodemus agrarius. (A) Round structures (black arrows) scattered in the lung. (B) Adiaspore was located in alveolar space encapsulated by granulomatous inflammatory lesion. Macrophages and Langerhans giant cells infiltrated in the surrounding granulomatous tissue. The spores have three layers in their walls and basophilc granular structures in their inner parts. Haematoxylin and Eosin stain. Bar=100 µm

Reference

1. Chantrey JC, Borman AM, Johnson EM, Kipar A. Emmonsia crescens infection in a British water vole (Arvicola terrestris). Med Mycol. 2006. 44(4):375–378.

2. Sigler L. Ajellomyces crescens sp. nov., taxonomy of Emmonsia spp., and relatedness with Blastomyces dermatitidis (teleomorph Ajellomyces dermatitidis). J Med Vet Mycol. 1996. 34(5):303–314.

3. Emmons CW, Jellison WL. Emmonsia crescens sp. n. and adiaspiromycosis (haplomycosis) in mammals. Ann N Y Acad Sci. 1960. 89:91–101.

4. Borman AM, Simpson VR, Palmer MD, Linton CJ, Johnson EM. Adiaspiromycosis due to Emmonsia crescens is widespread in native British mammals. Mycopathologia. 2009. 168(4):153–163.

5. Mendes MO, Moraes MA, Renoiner EI, Dantas MH, Lanzieri TM, Fonseca CF, Luna EJ, Hatch DL. Acute conjunctivitis with episcleritis and anterior uveitis linked to adiaspiromycosis and freshwater sponges, Amazon region, Brazil. Emerg Infect Dis. 2009. 15(4):633–639.

6. Wellinghausen N, Kern WV, Haase G, Rozdzinski E, Kern P, Marre R, Essig A, Hetzel J, Hetzel M. Chronic granulomatous lung infection caused by the dimorphic fungus Emmonsia sp. Int J Med Microbiol. 2003. 293(6):441–445.

7. Leighton FA, Wobeser G. The prevalence of adiaspiromycosis in three sympatric species of ground squirrels. J Wildl Dis. 1978. 14(3):362–365.

8. Simpson VR, Gavier-Widen D. Fatal adiaspiromycosis in a wild Eurasian otter (Lutra lutra). Vet Rec. 2000. 147(9):239–241.

9. Mörner T, Avenäs A, Mattsson R. Adiaspiromycosis in a European beaver from Sweden. J Wildl Dis. 1999. 35(2):367–370.

10. Hamir AN. Pulmonary adiaspiromycosis in raccoons (Procyon lotor) from Oregon. J Vet Diagn Invest. 1999. 11(6):565–567.

11. Hill JE, Parnell PG. Adiaspiromycosis in bullfrogs (Rana catesbeiana). J Vet Diagn Invest. 1996. 8(4):496–497.

12. Seixas F, Travassos P, Pinto ML, Pires I, Pires MA. Pulmonary adiaspiromycosis in a European hedgehog (Erinaceus europaeus) in Portugal. Vet Rec. 2006. 158(8):274–275.

13. Pusterla N, Pesavento PA, Leutenegger CM, Hay J, Lowenstine LJ, Durando MM, Magdesian KG. Disseminated pulmonary adiaspiromycosis caused by Emmonsia crescens in a horse. Equine Vet J. 2002. 34(7):749–752.

14. Barbas Filho JV, Amato MB, Deheinzelin D, Saldiva PH, de Carvalho CR. Respiratory failure caused by adiaspiromycosis. Chest. 1990. 97(5):1171–1175.

15. England DM, Hochholzer L. Adiaspiromycosis: an unusual fungal infection of the lung. Report of 11 cases. Am J Surg Pathol. 1993. 17(9):876–886.

16. Nuorva K, Pitkänen R, Issakainen J, Huttunen NP, Juhola M. Pulmonary adiaspiromycosis in a two year old girl. J Clin Pathol. 1997. 50(1):82–85.

17. Peres LC, Figueiredo F, Peinado M, Soares FA. Fulminant disseminated pulmonary adiaspiromycosis in humans. Am J Trop Med Hyg. 1992. 46(2):146–150.

18. Dot JM, Debourgogne A, Champigneulle J, Salles Y, Brizion M, Puyhardy JM, Collomb J, Plénat F, Machouart M. Molecular diagnosis of disseminated adiaspiromycosis due to Emmonsia crescens. J Clin Microbiol. 2009. 47(4):1269–1273.

19. Hubálek Z. Emmonsiosis of wild rodents and insectivores in Czechland. J Wildl Dis. 1999. 35(2):243–249.

20. Krivanec K, Otcenásek M, Prokopic J. Experimental adiaspiromycosis of the common vole (Microtus arvalis) and other small wild mammals after intraperitoneal inoculation. Mycopathol Mycol Appl. 1974. 53(1):133–140.

21. Boisseau-Lebreuil MT. In vitro formation of adiospores in 10 strains of Emmonsia cresens, the fungal agent of adiospiromycosis. C R Seances Soc Biol Fil. 1975. 169(4):1057–1061.