Korean J Urol.  2008 Feb;49(2):174-176.

Mixed Epithelial and Stromal Tumor of the Kidney

Affiliations
  • 1Department of Urology, Ajou University School of Medicine, Suwon, Korea. sejoong@ajou.ac.kr
  • 2Department of Pathology, Ajou University School of Medicine, Suwon, Korea.

Abstract

Mixed epithelial and stromal tumor of the kidney(MEST) is a rare, recently described benign renal neoplasm that predominantly affects perimenopausal women. It is composed of dual components of epithelial and stromal cells, and the tumor is characterized by admixed cystic and solid growth patterns. Herein, we report on a case of MEST in a 35-year-old woman who presented with an incidentally found renal tumor. The patient has had no evidence of disease 4 years after the surgery.

Keyword

Kidney neoplasms; Complex and mixed neoplasms; Epithelial cells; Stromal cells

MeSH Terms

Adult
Epithelial Cells
Female
Humans
Kidney
Kidney Neoplasms
Neoplasms, Complex and Mixed
Stromal Cells

Figure

  • Fig. 1 Contrast-enhanced CT scan shows a 5cm sized inhomogeneous mass on the right upper portion of the kidney.

  • Fig. 2 Bisected right kidney shows a round well-defined, pinkish white, partly solid and multifocally cystic yellowish rubbery mass involving the upper pole at the periphery, and the mass measured 4.5×4cm.

  • Fig. 3 The tumor is composed of variegated cellular stroma and multilocular cysts and tubules lined by columnar, cuboidal or flattened epithelial cells without atypia (H&E, ×100).


Reference

1. Michal M, Syrucek M. Benign mixed epithelial and stromal tumor of the kidney. Pathol Res Pract. 1998. 194:445–448.
2. Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ. Mixed epithelial and stromal tumor of the kidney. Am J Surg Pathol. 2000. 24:958–970.
3. Jevremovic D, Lager DJ, Lewin M. Cystic nephroma (multilocular cyst) and mixed epithelial and stromal tumor of the kidney: a spectrum of the same entity? Ann Diagn Pathol. 2006. 10:77–82.
4. Turbiner J, Amin MB, Humphrey PA, Srigley JR, De Leval L, Radhakrishnan A, et al. Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathological analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol. 2007. 31:489–500.
5. Kwon JE, Kang JH, Kwon GY. Mixed epithelial and stromal tumor of the kidney: a case report. J Korean Med Sci. 2007. 22:159–162.
6. Park HS, Kim SH, Kim SH, Paik JH, Hwang SI, Jung SI, et al. Benign mixed epithelial and stromal tumor of the kidney: imaging findings. J Comput Assist Tomogr. 2005. 29:786–789.
7. Comperat E, Couturier J, Peyromaure M, Cornud F, Vieillefond A. Benign mixed epithelial and stromal tumor of the kidney (MEST) with cytogenetic alteration. Pathol Res Pract. 2005. 200:865–867.
8. Yap YS, Coleman M, Olver I. Aggressive mixed epithelial-stromal tumour of the kidney treated with chemotherapy and radiotherapy. Lancet Oncol. 2004. 5:747–749.
9. Nakagawa T, Kanai Y, Fujimoto H, Kitamura H, Furukawa H, Maeda S, et al. Malignant mixed epithelial and stromal tumours of the kidney: a report of the first two cases with a fatal clinical outcome. Histopathology. 2004. 44:302–304.
10. Svec A, Hes O, Michal M, Zachoval R. Malignant mixed epithelial and stromal tumor of the kidney. Virchows Arch. 2001. 439:700–702.
Full Text Links
  • KJU
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr