Korean J Urol.  2008 Feb;49(2):127-133.

The Effect of the Serum Cholesterol Level on the Clinicopathologic Characteristics of Prostate Cancer

• Sung W
• Jeon SH
• Chang SG

Abstract

PURPOSE
We assessed the relationship between the serum cholesterol level and the clinicopathologic characteristics of prostate cancer patients who had undergone a radical retropubic prostatectomy. MATERIALS AND METHODS: We enrolled 70 prostate cancer patients who had relevant data available for this study. All of the patients had their serum cholesterol level checked at least three times for a month preoperatively. We divided them into three groups according to: 1) a mean preoperative cholesterol level less than 180mg/dl, 2) between 180mg/dl and 200mg/dl, and 3) more than 200mg/dl. The serum cholesterol levels and other clinicopathologic characteristics were then compared and analyzed. The clinicopathologic findings included the pathologic T stage, Gleason score, prostate-specific antigen(PSA) and the other pathologic findings that included perineural invasion, vascular invasion, lymphatic invasion and capsular invasion. All the data was retrospectively collected from the patients' medical records. RESULTS: The mean cholesterol level was 181.1+/-4.1mg/dl. There was a statistically significant difference in the incidence of perineural invasion among these three groups according to the cholesterol level, with linear correlation(p=0.015). This correlation was more significant among the T2 patients or the patients with a total PSA value of 4ng/dl to 10ng/dl. Furthermore, the preoperative serum cholesterol level was significantly affected by the pathologic finding of perineural invasion(p=0.024, odd ratio=3.565). CONCLUSIONS: There was a direct correlation between the increase incidence of perineural invasion with the increased preoperative serum cholesterol level for prostate cancer patients who had undergone radical prostatectomy.

Keyword

Prostatic cancer; Cholesterol; Prostatectomy

MeSH Terms

Cholesterol
Humans
Incidence
Medical Records
Neoplasm Grading
Prostate
Prostatectomy
Prostatic Neoplasms
Retrospective Studies
Cholesterol

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