Korean J Urol.
2009 Feb;50(2):195-198.
Familial Prostate Cancer in Three Brothers
- Affiliations
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- 1Urologic Oncology Clinic, National Cancer Center, Goyang, Korea. uroonco@ncc.re.kr
- 2Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
- 3Gachon University of Medicine and Science, Incheon, Korea.
- 4Department of Pathology, National Cancer Center, Goyang, Korea.
Abstract
- We treated a family of 3 brothers with prostate cancer, which is the first report of familial prostate cancer in Korea. Prostate cancer was diagnosed in the first brother with a prostate-specific antigen (PSA) level of 12.70 ng/ml of at the age of 68 years. He underwent a radical retropubic prostatectomy (RRP); the cancer was pathologically staged to T2cN1Mo. He received adjuvant hormonal therapy postoperatively. Three years later, prostate cancer was diagnosed in the third brother at the age of 61 years with a high PSA level of 4.45 ng/ml. He underwent RRP, which revealed the pathological stage to be T2cN0M0. Three months later, the second brother, who had visited our hospital for lower urinary tract symptoms and for a PSA screening test was diagnosed with prostate cancer at the age of 60 years (PSA level of 3.96 ng/ml). He also underwent RRP, and his cancer was staged pathologically as T2cN0M0.
Keyword
MeSH Terms
Figure
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Fig. 1 Three brothers' familial pedigree.
Reference
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1. Carter BS, Bova GS, Beauty TH, Steinberg GD, Childs B, Isaacs WB, et al. Hereditary prostate cancer: epidemiologic and clinical features. J Urol. 1993. 150:797–802.2. Steinberg GD, Carter BS, Beaty TH, Childs B, Walsh PC. Family history and the risk of prostate cancer. Prostate. 1990. 17:337–347.3. Spitz MR, Currier RD, Fueger JJ, Babaian RJ, Newell GR. Familial patterns of prostate cancer: a case-control analysis. J Urol. 1991. 146:1305–1307.4. Klein EA, Platz EA, Thomson IM. Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA, editors. Epidemiology, etiology, and prevention of prostate cancer. Campbell-Walsh urology. 2007. 9th ed. Philadelphia: Saunders;2857–2858.5. Woolf CM. An investigation of the familial aspects of carcinoma of the prostate. Cancer. 1960. 13:739–744.6. Bratt O. Hereditary prostate cancer: clinical aspects. J Urol. 2002. 168:906–913.7. Eeles RA, Dearnaley DP, Ardern-Jones A, Shearer RJ, Easton DF, Ford D, et al. Familial prostate cancer: the evidence and the Cancer Research Campaign/British Prostate Group (CRC/BPG) UK Familial Prostate Cancer Study. Br J Urol. 1997. 79:Suppl 1. 8–14.8. Lee SE. Diagnosis of prostate cancer. Korean J Urol. 2004. 45:197–208.9. Hwang KH, Chung MK. Screening for prostatic cancers in Korean. Korean J Urol. 1995. 36:1062–1070.10. Gillanders EM, Xu J, Chang BL, Lange EM, Wiklund F, Bailey-Wilson JE, et al. Combined genome-wide scan for prostate cancer susceptibility genes. J Natl Cancer Inst. 2004. 96:1240–1247.
