Korean Lepr Bull.  2008 Dec;41(2):17-22.

Hydoroxocobalamin (Vitamin B12) Effects on Nerve Function Impairments in Leprosy

• Lee KD

Abstract

95 patients in Sorokdo national hospital injected 1-5mg Hydroxocobalamin (5mg/2ml/1ample) in 5-7 days/week, duration 6.4 months, average age 71.6 years old. Effects are 1) softening of hand movement(22/95), early effect, 2) improving of motor function (8/95) 3) sensory function(8/95) 4) sweating (3/95) 5) neuropathic pain and headache(neuralgia-like) (7/95) 6) jaw and hand tremor (7/95) 7) no response (41/95) 8) side effect (1/95) Leprosy is demyelinating peripheral neuropathy, Vitamin B12 effects on myelin, but unkown it's mechnism. Vitamin B12 improve nerve function impairments in leprosy, especially neuropathic pain and tremor, which lead to deformities and disabilities.

Keyword

Leprosy; Nerve function impairment; Neuralgia; Tremor; Hydroxocobalamin(Vitamin B12)

MeSH Terms

Congenital Abnormalities
Hand
Humans
Hydroxocobalamin
Jaw
Leprosy
Myelin Sheath
Neuralgia
Peripheral Nervous System Diseases
Sweat
Sweating
Tremor
Vitamin B 12
Hydroxocobalamin
Vitamin B 12