Korean J Nephrol.
1997 Sep;16(3):578-583.
Coexistence of Membranous Glomerulonephritis and IgA Nephropathy in a Patient with Psoriasis Vulgaris
- Affiliations
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- 1Department of Internal Medicine, Samsung Seoul Hospital, College of Medicine, Sun Kyun Kwan University, Seoul, Korea.
- 2Department of Diagnostic Pathology Samsung Seoul Hospital, College of Medicine, Sun Kyun Kwan University, Seoul, Korea.
- 3Department of Internal Medicine, Gyeong Sang National University, Seoul, Korea.
Abstract
- A 17-year-old man with psoriasis developed albuminuria and microscopic hematuria. Renal biopsy revealed a glomerulonephritis with features of both membranous glomerulonephritis and IgA nephropathy. Histologically the glomeruli exhibited variable degree of mesangial expansion and hypercellularity, three of which showed segmental hyalinosis and/or sclerosis. Direct immunofluorescence demonstrated granular IgG-bearing deposits along the peripheral glomerular capillaries and IgA deposits in the mesangium. His urinary abnormalities persisted after the remission of skin lesion induced by PUVA treatment. It suggests that although the psoriasis may induce the renal lesion, it is insufficient to treat only the skin lesion for clinical improvement of glomerulonephritis after the renal lesion is already established.
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