Korean J Nephrol.
1999 Nov;18(6):965-973.
Patients' Referral Pattern and Dialysis Initiation Practice: Single Center Experience
Abstract
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Despite improvements in dialysis care, the mortality of patients with end-stage renal
disease(ESRD) remains high. One factor that has so far received little attention,
but which might contribute to morbidity and mortality, is the timing of referral to
the nephrologist. We performed a retrospective analysis in 358 patients(male 275, female 151)
who were initiated renal replacement therapy first at this hospital from Jan 1995 to Dec 1996.
Patients were defined by the time of first nephrology as early referral(E, n=163) encountered
after more than 8 weeks; late early referral(LE, n=19) encountered between 8 weeks and 4 weeks;
late referral(L, n=55) encountered from 1 week to 4 weeks; urgent referral(U, n= 121)
encountered less than 1 week. There were no differences in age, gender, primary renal disease,
cause of dialysis, and renal replacement therapy modalities. However, there were significant
differences in rnean arterial pressure and serum phosphate levels between these 4 groups.
The mean arterial pressures (mmHg) were 109.15 +/- 17.16, 105.37+/-18.76, 117.24 +/- 27.24 and
116.98+/-24.26 for E, LE, L and U, respectively(p<0.05, compared E to U). In the U group,
serum phosphate levels were elevated at initiation of dialysis compared to
the E group(6.39+/-1.72 vs 7.29 +/- 3.54mg/dL, p<0.05). One year mortality in the U group had
on increased tendency compared to the E group, especially earlier mortality(7.4% vs 14.9N,
p>0.05). In the E group, there was more controlled blood pressure and serum phosphate levels
compared to the U group at initiation of renal replacement therapy, but other parameters were
not significantly different among the 4 groups. Delays in initiation of renal replacement
therapy may result in patients entering dialysis in a compromised state, therefore adequate
long-term predialysis care by a nephrologist is important. Socioeconomic - and medical factors
respon-sible for late referral and late initiation of dialysis need to be evaluated and
corrected to further improve the outcome of these patients.