Korean J Med.
2000 Oct;59(4):413-422.
Mantle cell lymphoma presented as multiple lymphomatous polyposis: clinical review of 4 cases
- Affiliations
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- 1Department of Internal Medicine, Kyungpook National University, School of Medicine, Taegu, Korea.
- 2Department of Clinical Pathology, Kyungpook National University, School of Medicine, Taegu, Korea.
- 3Department of Pathology, Kyungpook National University, School of Medicine, Taegu, Korea.
- 4Cancer Research Institute, Kyungpook National University, School of Medicine, Taegu, Korea.
Abstract
- Multiple lymphomatous polyposis(MLP) is an interesting clinical entity of non-Hodgkin's lymphoma(NHL) and is defined as B-cell lymphoma characterized by the presence of multiple lymphomatous polyps along the gastrointestinal tract. Recently MLP has been considered as a variant form of mantle cell lymphoma(MCL). The median survival of patients with MCL is only 3 years, and none of the available conventional chemotherapy regimens appears curative. Encouraging results have been reported with high dose chemotherapy with autoSCT and alloSCT for its treatment. We introduce 4 cases of MLP diagnosed as MCL by morphologic and immunologic method. The common clinical findings of these cases were splenomegaly (4/4), multiple intraabdominal lymphadenopathy (4/4), and advanced stage (3/4) at presentation. The overall remission duration was relatively short (5-27 months) and three of four cases relapsed after conventional chemotherapy or autologous stem cell transplant. Our report suggests that MCL presented as MLP is a high risk subgroup of NHL and more aggressive approach may be needed for cure.
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