Korean J Med.  2002 Oct;63(4):357-368.

A prospective study of Helicobacter pylori reinfection rate and related factors in Gyeongju-si residents

• Doh JH
• Kang PS
• Hwang TY
• Lee KS
• Kim SB
• Kim SK
• Kim HG

Abstract

BACKGROUND: High prevalence of Helicobacter pylori (H. pylori) in developing countries may result in high reinfection rate after eradication therapy, but there were few studies on H. pylori reinfection, especially in community population. The aim of this study was to investigate the one -year reinfection rate of H. pylori after successful eradication therapy and the factors related to the reinfection of H. pylori in community population.
METHODS
86 persons who had been confirmed as H. pylori-negative by 13C-urea breath test were included. They were ones of 181 persons treated by eradication regimen one year ago because of H. pylori-positive in serologic H. pylori antibody test and rapid urease test. The reinfection rate of H. pylori and the factors related to the reinfection of H. pylori were investigated after one-year follow-up. The subjects were confirmed as H. pylori reinfection by repetitive 13C-urea breath test and asked to answer the questionnaire regarding demographic characteristics, dyspepsia symptoms, health-related behaviors and family history.
RESULTS
The one-year reinfection rate was 18.6% in this study. The one-year reinfection rate of the subjects who aged above 50 years was 23.4% (p < 0.05). The symptom score (total 5) was positively related to H. pylori reinfection (p < 0.05). In multivariate logistic regression analysis, the subjective symptom score was the significant factor in predicting H. pylori positivity by 13C-urea breath test (OR=4.5, p < 0.05).
CONCLUSION
During 1 year period after successful H. pylori eradication, the reinfection rate of H. pylori was 18.6%. The subjective symptom score survey by questionnaire may be useful predictor of H. pylori reinfection in community setting.

Keyword

Helicobacter pylori; reinfection; 13C-urea breath test

MeSH Terms

Breath Tests
Developing Countries
Dyspepsia
Follow-Up Studies
Gyeongsangbuk-do*
Helicobacter pylori*
Helicobacter*
Humans
Logistic Models
Prevalence
Prospective Studies*
Urease
Surveys and Questionnaires
Urease