Gastric metaplasia and Helicobacter pylori infection of duodenal mucosa in duodenal ulcer

Park, Kyung Sik; Kwon, Ki Min; Jang, Byoung Kuk; Hwang, Jun Young; Chung, Woo Jin; Cho, Kwang Bum; Hwang, Jae Seok; Ahn, Sung Hoon; Kang, Yu Na; Kim, Gab Chul; Kwon, Jung Hyeok

Abstract

BACKGROUND: The roles of gastric metaplasia and Helicobacter pylori (H. pylori) infection of duodenal mucosa in the pathogenesis of duodenal ulcer has been emphasized. Though there are a few reports which compared degree of these two risk factors between the duodenal ulcer and control groups, the reports which compared ulcer site with nonulcer site within ulcer group are rare. The aim of this study was to compare the frequencies of gastric metaplasia and H. pylori infection between both sites within ulcer group, as well as between both groups.
METHODS
The active duodenal ulcer patients group (n=30) and control group (n=31) were selected. The frequency of gastric metaplasia and H. pylori infection were compared among the ulcer sites, the nonulcer sites of ulcer patients, and the intact duodenal mucosa of controls.
RESULTS
The frequencies of gastric metaplasia and H. pylori infection were higher at ulcer sites than nonulcer sites within ulcer group, however, there were no differences between the nonulcer sites of ulcer group and control group. Positivities of H. pylori infection at metaplastic area were not different at 3 compared sites.
CONCLUSION
It seems that duodenal ulcer develop more frequently at area of gastric metaplasia infected by H. pylori. However, further evaulation about the pathogenesis of duodenal ulcer is necessary because there are lots of duodenal ulcer cases which are not accompanied by gastric metaplasia.