Korean J Epidemiol.  2003 Jun;25(1):32-38.

Epidemiological Comparison of viral hepatitis-hepatocellular carcinoma(HCC) and non viral hepatitis-hepatocellular carcinoma(HCC)

• Park PG
• Yoon SG
• Lee HS
• Jang JK
• Maeng JH
• Lee GH
• Choi JS

Abstract

BACKGROUND
Korea is one of high incidence areas of Hepatocellular carcinoma (HCC) and major etiologic factor is hepatitis B virus (HBV). In future incidence of HBV related HCC may decrease and non viral hepatitis HCC (Non-B,C HCC) relatively increase because of widely used vaccination for HBV. To evaluate epidemiological characters of Non-B,C HCC, We divided HCC by viral or non-viral feature and compared each others.
METHODS
185 patients firstly diagnosed HCC and 455 normal subjects included from January 1997 to December 2000 and divided into 3 groups, HBV group (positive HBsAg), HCV group (positive anti-HCV Ab) and Non-B,C group (both negative HBsAg and anti-HCV Ab).
RESULTS
136 cases were HBV group (73.5%), 19 cases were HCV group (10.3%) and 27 cases were Non-B,C group (14.6%). Mean age of Non-B,C group at diagnosis was higher than HBV group (64.1+/-7.1 vs 55.6+/-7.7). Non-B,C HCC were more associated with alcohol abuse and rural residence (p<0.01). There was no difference of family history of liver disease, coexistence rate of liver cirrhosis and occupation.
CONCLUSION
Non-B,C HCC tended to be older in mean age than HBV HCC and more associated with alcohol abuse and rural residence. This characteristics of Non-B,C HCC supposed to be from difference in alcohol consumption and environment.

Keyword

Viral hepatitis; Hepatocellular carcinoma; Non B,C-hepatocellular carcinoma

MeSH Terms

Alcohol Drinking
Alcoholism
Carcinoma, Hepatocellular
Diagnosis
Fibrinogen
Hepatitis
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Incidence
Korea
Liver Cirrhosis
Liver Diseases
Occupations
Vaccination
Fibrinogen
Hepatitis B Surface Antigens