Korean J Dermatol.  2007 Aug;45(8):851-854.

A Case of Delayed Hypersensitivity to Enoxaparin in Patient with Deep Vein Thrombosis

• Jwa SW
• Kim SJ
• Ko HC
• Kim MB
• Kwon KS
• Oh CK

Abstract

Enoxaparin, a low-molecular-weight heparin, is widely used to prevent and treat thromboembolic diseases due to its improved pharmacodynamic properties and better safety profile than unfractionated heparins. Although the most common complication is bleeding, enoxaprin has also been implicated in skin manifestations such as urticaria, bruising, angioedema and skin necrosis. Rarely, cases have been reported of eczema-like plaques caused by delayed hypersensitivity after administration of enoxaparin injections. However, there is no report to describe delayed hypersensitivity to enoxaparin in Korean literature. We present herein a case of delayed hypersensitivity to enoxaparin, which is very rare case but needs the attention of special departments such as dermatologists as well as internalists and phlebologists.

Keyword

Deep vein thrombosis; Delayed hypersensitivity; Enoxaparin

MeSH Terms

Angioedema
Enoxaparin*
Hemorrhage
Heparin
Heparin, Low-Molecular-Weight
Humans
Hypersensitivity, Delayed*
Necrosis
Skin
Skin Manifestations
Urticaria
Venous Thrombosis*
Enoxaparin
Heparin
Heparin, Low-Molecular-Weight