Korean J Biol Psychiatry.
2010 Nov;17(4):218-225.
The Impact of Choline Acetyltransferase Polymorphism on the Expression of Mild Cognitive Impairment
- Affiliations
-
- 1Department of Psychiatry, Kyungpook National University Hospital, Daegu, Korea.
- 2Department of Psychiatry, Jeju National University Hospital, Jeju, Korea.
- 3Department of Psychiatry, Dankook University Hospital, Cheonan, Korea.
- 4Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea. kwkimmd@snu.ac.kr
- 5Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Korea.
- 6Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, Korea.
- 7Department of Psychiatry, Seoul National University Hospital, Seoul, Korea.
- 8Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
- 9Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Abstract
OBJECTIVES
The potential association between choline acetyltransferase(CHAT) polymorphism and the risk of mild cognitive impairment(MCI) has not been investigated in Korea. We examined the main effect of CHAT polymorphism and its interaction with apolipoprotein E(APOE) polymorphism in the development of MCI in elderly Korean sample.
METHODS
We analyzed CHAT 2384G > A polymorphism and APOE polymorphism among 149 MCI subjects with MCI and 298 normal controls. We tested the association between MCI and CHAT A allele status using a logistic regression model. In addition, we employed generalized multifactor dimensionality reduction(GMDR) to investigate the interaction between CHAT and APOE with regard to the risk of MCI.
RESULTS
The CHAT A allele was associated with AD risk(OR = 1.59, 95% CI = 1.02-2.48, p = 0.042). No significant gene-gene interaction between CHAT and APOE was found in GMDR method(testing balanced accuracy = 0.540, p = 0.055).
CONCLUSION
The CHAT A allele was associated with MCI risk in the Korean elderly. Its interaction with the APOE epsilon4 allele was not significant with regard to the development of MCI.
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