Korean J Asthma Allergy Clin Immunol.  2007 Mar;27(1):61-65.

A Case of Myeloproliferative Variant of Hypereosinophilic Syndrome with Increased Serum Tryptase Evolving into Chronic Eosinophilic Leukemia

Abstract

A 72-year-old male patient was referred to the hematologic department because of persistent hypereosinophilia, splenomegaly and chronic fatigue; these existed for 3 months. A presumptive diagnosis of a myeloproliferative variant of hypereosinophilic syndrome was made on the basis of anemia, splenomegaly, bone marrow hypercelluarity, increased serum tryptase and vitamine B12. Fip 1 like 1-platelet- driven growth factor receptor alpha fusion gene and platelet- driven growth factor receptor beta gene rearrangement anal-ysis with RT PCR were negative. In initial therapeutic approach with prednisolone, hydroxyurea, and imatinib mesyalte, blood eosniophilia did not improve and transformation into chronic eosinophilic leukemia observed in the peripheral blood smear. In the case herein reported, therapeutic response was not achieved with cytosine arabinoside chemotherapy.

MeSH Terms

Aged
Anemia
Bone Marrow
Cytarabine
Diagnosis
Drug Therapy
Eosinophils*
Fatigue
Gene Rearrangement
Humans
Hydroxyurea
Hypereosinophilic Syndrome*
Leukemia
Male
Polymerase Chain Reaction
Prednisolone
Splenomegaly
Tryptases*
Vitamins
Imatinib Mesylate
Cytarabine
Hydroxyurea
Prednisolone
Tryptases
Vitamins