Korean Diabetes J.  2009 Apr;33(2):105-112. 10.4093/kdj.2009.33.2.105.

The Relationship between Serum Retinol-Binding Protein 4 Levels and Coronary Artery Disease in Korean Adults

• Kim JH
• Rhee EJ
• Choi ES
• Won JC
• Park CY
• Lee WY
• Oh KW
• Kim BJ
• Sung KC
• Kim BS
• Kang JH
• Park SW
• Kim SW
• Lee MH
• Park JR

• KMID: 2298067
• DOI: http://doi.org/10.4093/kdj.2009.33.2.105

Abstract

BACKGROUND
A recently discovered adipokine, retinol-binding protein-4 (RBP-4), is reportedly associated with insulin resistance and metabolic syndrome. This study was performed to analyze the relationship between serum RBP-4 levels and coronary artery disease (CAD) in Korean adults. METHODS: In 235 subjects (mean age 58 years) in whom coronary artery angiograms were performed due to complaints of chest pain, serum RBP-4 levels were measured by enzyme-linked immunosorbent assay. Coronary artery angiograms were performed in all subjects and the severity of CAD was assessed by the number of stenotic vessels. The presence of metabolic syndrome was defined by AHA/NHLBI criteria with body mass index substituted for waist circumference. RESULTS: Coronary angiogram showed that 101 subjects (43%) had normal coronary vessel, 82 subjects (34.9%) had 1-vessel disease, 31 subjects (13.2%) had 2-vessel disease and 21 subjects (8.9%) had 3-vessel disease. Subjects with coronary artery stenosis showed a higher mean age (60.5 +/- 10.0 years), fasting glucose (123.3 mg +/- 45.0 mg/dL) and lower mean value for high-density lipoprotein cholesterol (HDL-C) level (49.0 +/- 13.2 mg/dL), although serum RBP-4 levels were not significantly different between those with and without CAD. Mean age and fasting glucose level increased significantly as the number of stenotic vessels increased, although serum RBP4 level showed no significant differences among the different groups. Among the metabolic parameters, only serum triglyceride levels showed a significant correlation with serum RBP-4 levels. CONCLUSION: There was no difference in mean serum RBP-4 levels between subjects with or without coronary artery disease in Korean adults. Further studies are warranted to draw a clear conclusion on the effect of RBP-4 on atherosclerosis.

Keyword

Atherosclerosis; Coronary artery disease; Retinol-binding protein-4

MeSH Terms

Adipokines
Adult
Atherosclerosis
Body Mass Index
Chest Pain
Cholesterol
Coronary Artery Disease
Coronary Stenosis
Coronary Vessels
Enzyme-Linked Immunosorbent Assay
Fasting
Glucose
Glycosaminoglycans
Humans
Insulin Resistance
Lipoproteins
Waist Circumference
Adipokines
Cholesterol
Glucose
Glycosaminoglycans
Lipoproteins

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