J Korean Acad Fam Med.  2003 May;24(5):456-460.

The Association between C-Reactive Protein and Features of the Metabolic Syndrome

• Kim YJ
• Hwang SB
• Kim SY
• Hwang IH

Abstract

BACKGROUNG: The Metabolic Syndrome is highly associated with an increased risk of coronary heart disease. C-reactive protein (CRP), a sensitive systemic marker of inflammation, is considered to show an association with risk of coronary heart disease. This study was done to assess the association of circulating levels of CRP with different components of the Metabolic Syndrome.
METHODS
Total cholesterol (TC), triglycerides (TG), HDL cholesterol, body mass index (BMI), waist circumference, fasting glucose, hemoglobin A1c (HbA1c), blood pressure (BP), and CRP were measured in 1,203 men and women who have visited the Health Promotion Center in Kangdong Sacred Heart Hospital. The relationship of CRP and variables of the metabolic syndrome using t-test and regression analysis as assessed.
RESULTS
CRP was associated with BMI (P<0.001), waist circumference (P<0.0001), diastolic blood pressure (P= 0.004), HDL cholesterol (P=0.015), and TG (P<0.0001). Subjects with the Metabolic Syndrome had a significantly higher CRP concentration (0.89 mg/L) than individuals without the metabolic syndrome (0.33 mg/L, P<0.0001).
CONCLUSION
CRP seems to be related to variables of the metabolic syndrome. The data suggest that a variety of features of the metabolic syndrome are associated with systemic inflammation.

Keyword

metabolic syndrome; C-reactive protein; inflammation

MeSH Terms

Blood Pressure
Body Mass Index
C-Reactive Protein*
Cholesterol
Cholesterol, HDL
Coronary Disease
Fasting
Female
Glucose
Health Promotion
Heart
Humans
Inflammation
Male
Triglycerides
Waist Circumference
C-Reactive Protein
Cholesterol
Cholesterol, HDL
Glucose
Triglycerides