J Korean Acad Fam Med.  2004 Mar;25(3):233-243.

The Effect of Hormone Replacement Therapy and Related Factors on the Change of Bone Mineral Density in Early Postmenopausal Women in Ulsan-si, Korea

• Jeong TH
• Kim CY
• Sa KJ
• Kim MC
• Kim CS

Abstract

BACKGROUND: Hormone replacement therapy (HRT) has been used as a effective therapeutic strategy of postmenopausal osteoporosis. However, the studies on HRT are insufficient, particularly in early postmenopausal women in Korea. This study was designed as a community based clinical trial and was conducted for 1 year.
METHODS
One hundred and forty early postmenopausal women aged 49 to 54 years who resided in Ulsan in Korea were enrolled in this study. The osteoporosis prone life style and general characteristics of the participants and their measured BMD were investigated. The therapy groups included 45 women who were assigned to one of the following regimens in 28 day cycles for 1 year: (1) conjugate equine estrogen (CEE), 0.625 mg/d daily, medroxyprogesterone acetate (MPA) 2.5 mg/d daily and calcium 500 mg/d daily (2) CEE 0.625 mg/d daily, MPA 10 mg/d for days 1 through 12 and calcium 500 mg/d daily.
RESULTS
The women in the therapy groups had an average gain of 5.4%, 4.2%, 2.1%, 4.9% in BMD in the lumbar spine, femur total, femur neck and ward's area, respectively. HRT has significantly influenced the BMD after controlling age, month since menopause, alcohol intake, smoking, calcium intake, exercise, body mass index and baseline BMD. The baseline BMD and the BMI were factors that influenced the effect of HRT in BMD.
CONCLUSION
HRT had positively influenced the BMD in Korean women. The baseline BMD and the BMI were predictors of the effect of HRT in BMD change.

Keyword

community; early postmenopausal women; hormone replacement therapy; bone density; factor

MeSH Terms

Body Mass Index
Bone Density*
Calcium
Estrogens
Female
Femur
Femur Neck
Hormone Replacement Therapy*
Humans
Korea
Life Style
Medroxyprogesterone Acetate
Menopause
Osteoporosis
Osteoporosis, Postmenopausal
Smoke
Smoking
Spine
Ulsan
Calcium
Estrogens
Medroxyprogesterone Acetate
Smoke