J Korean Acad Fam Med.
2006 Jan;27(1):33-41.
Mammographic Breast Density and Risk Factors of Breast Cancer in Korean Women Using Multicenter Study
- Affiliations
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- 1Department of Family Medicine, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea. jjcho@dreamwiz.com
- 2Department of Radiology, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
- 3Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 4Department of Radiology, Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 5Department of Family Medicine, Ilsan Paik Hospital, Inje University, Ilsan, Korea.
- 6Department of Family Medicine, Seoul Paik Hospital, Inje University, Seoul, Korea.
- 7Department of Family Medicine, Kangwon National University, Chuncheon, Korea.
- 8Department of Radiology, College of Medicine, Kangwon National University, Chuncheon, Korea.
- 9Department of Radiology, Gangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
Abstract
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BACKGROUND: Density patterns on mammography have been related to the risk factors for breast cancer in the western countries. High mammographic density appears to confer a 4-fold risk of breast cancer. While the proportion of high-density mammography is higher in Korean women than in Caucasian women, the incidence of breast cancer in Korean women is considerably lower. Therefore, we examined if the mammographic breast density pattern correlates with the risk factors for breast cancer in Korean women.
METHODS
In a cross-sectional design, we recruited 1,758 pre- and post-menopause women without prior history of breast cancer and breast surgery who underwent screening mammogram and completed a self-administered questionnaire in 6 general hospitals. On the basis of ACR BI RADS breast composition, four density patterns were classified in caudocranial and mediolateral mammography by a designated radiologist in each hospital. Multiple linear logistic regression was used for statistical analyses.
RESULTS
Inter-rater reliability between the initial report and the report made by another blinded radiologist was high (Pearson's co-efficient=0.81). Overall, the age, body mass index, family history of breast cancer, and duration of hormone replacement therapy correlated with the mammographic density patterns. In pre-menopausal women, the high body mass index and parity (=2) were associated with low mammographic density. In post- menopausal women, older age, high body mass index, negative family history of breast cancer, and duration of hormone replacement therapy were associated with low mammographic density.
CONCLUSION
Our data showed that the mammographic breast density patterns correlated with risk factors for breast cancer in Korean women. While the proportion of high-density mammography is higher in Korean women, the incidence of breast cancer is lower than in the western population. This maybe dependent on other unknown factors. (J Korean Acad Fam Med 2006;27: 33-41)
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