Korean J Urol.  2003 Jan;44(1):1-5.

Predictive Factors of Prostatic Cancer Detection on Repeat Prostate Biopsy

• Ryu SH
• Chai SE
• Choi HY

Abstract

PURPOSE: To determine the demographic and tumor related predictors of repeat biopsy cancer detection in men diagnosed with benign prostatic tissue following an initial prostate biopsy. We evaluated the clinical parameters of prostate cancers detected on repeat biopsy.
MATERIALS AND METHODS
Between May 1994 and 2001, 1,016 patients with suspected prostatic cancer underwent a transrectal ultrasound guided prostate biopsy. Of the 721 patients whose biopsy specimens were negative for prostate cancer, 53 had a repeat prostate biopsy for persistently, or abruptly elevated, prostate specific antigen (PSA) values. We examined their serum PSA, PSA density, free to total PSA value, annualized interbiopsy PSA change and biopsy core numbers, as well as their age, prostate size and the histological results of their initial, and repeated, biopsies, to determine if any predictor of the need for a repeat biopsy could be identified.
RESULTS
From the repeat biopsies, 15 patients (28.3%) had prostate cancer. There were significant differences between the benign and malignant repeat biopsies, in relation to PSA density (p=0.001), free to total PSA value (p=0.002) and annualized interbiopsy PSA change (p=0.001). No patient with high-grade prostatic intraepithelial neoplasia was subsequently found to have cancer.
CONCLUSIONS
The PSA density, free to total PSA value and annualized interbiopsy PSA change appear to aid in the prediction of cancer on a repeat biopsy.

Keyword

Prostate biopsy; Prostate cancer; Predictive factor

MeSH Terms

Biopsy*
Humans
Male
Prostate*
Prostate-Specific Antigen
Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms*
Ultrasonography
Prostate-Specific Antigen