Korean J Urol.  2002 Apr;43(4):303-307.

Can Bladder Capacity and Urine Specific Gravity as well as Other Variables Predict the Responsiveness to Desmopressin in Enuretic Children?

• Cho HM
• Park JS
• Lee JY

Abstract

PURPOSE
The relationship of the functional bladder capacity and the urine specific gravity, as well as other variables, to the responsiveness to desmopressin in children with nocturnal enuresis was investigated. MATERIALS AND MTHODS: A total of 57 children with nocturnal enuresis who visited our outpatient department were evaluated based on their charts. The predictors of the response evaluated includes age, the number of wet nights, the urine specific gravity, and the maximum functional bladder capacity [as a percentage of predicted bladder capacity based on Satoshi Hamano's formula (patient age 2)x25=cc]. Responders to desmopressin were classified as excellent (less than 2 nights of wetting/14 nights), good (50% or greater decrease but more than 2 nights wetting/14 nights) and non responders, who were defined by a less than 50% decrease in wet nights.
RESULTS
Of the 46 patients who were evaluated, 20 (43.5%) achieved an excellent response to desmopressin. Twelve (26.1%) patients were good responders and 14 (30.4%) were non responders. The cumulative rate of the good and non-responders was 26 (56.5%). There were no significant differences in the bladder capacity ratio, age, and the number of wet nights. However, response to desmopressin was significantly associated with the urine specific gravity (p<0.05).
CONCLUSIONS
The urine specific gravity was found to be a significant prognostic factors of the response to desmopressin.

Keyword

Enuresis; Desmopressin; Urine specific gravity; Bladder capacity

MeSH Terms

Child*
Deamino Arginine Vasopressin*
Enuresis
Humans
Nocturnal Enuresis
Outpatients
Specific Gravity*
Urinary Bladder*
Deamino Arginine Vasopressin