J Korean Acad Adult Nurs.  2008 Dec;20(6):917-931.

Assessment of the Optimum LDL : HDL-cholesterol(LDL : HDL-C) Ratio for Predicting CHD

Affiliations
  • 1Department of Nursing, Seoil College, Korea. yeoumsg@seoil.ac.kr

Abstract

PURPOSE: This study was aimed to determine the optimum low-density lipoprotein : high-density lipoprotein-cholesterol (LDL : HDL-C) ratio for predicting coronary heart disease(CHD) in Korean people.
METHODS
It was analyzed this data of 5,431 adults who had undergone health examinations in a hospital in Gyeonggi-do between January 2006 and December 2007. The covariation of the coronary risk factors such as age, HbA1C, systolic blood pressure(SBP), and waist-to-stature ratio(WSR) were analyzed by using logistic regression analysis.
RESULTS
The LDL : HDL-C ratio in the male and female groups was mostly distributed between 1.5 and 4.0. The LDL : HDL-C ratio was the most significant cholesterol-related parameter influencing CHD(male: B = .306, p = .054, female : B = .940, p = .010), followed by LDL-C and total cholesterol. It was observed a sharp increase in the odds ratios for LDL : HDL-C ratios of 2.25 - 2.50(male) and 2.00 - 2.25(female). A significant difference was observed in both male(2.25 : chi-square = 2.494, p = .072) and female(2.00 : chi-square = 413.742, p = .000) groups.
CONCLUSION
The risk level of CHD was set to 2.25 for males and 2.00 for females. Therefore, the optimum LDL : HDL-C ratio for Koreans should be far lower than that for the people in western countries.

Keyword

Coronary heart disease; LDL; HDL; Cholesterol

MeSH Terms

Adult
Cholesterol
Coronary Disease
Female
Heart
Humans
Lipoproteins
Logistic Models
Male
Odds Ratio
Risk Factors
Cholesterol
Lipoproteins
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