Korean J Urol.  1999 Aug;40(8):997-1002.

The Effect of Age, Prostate volume and Total PSA on Percent free PSA in Men with Benign Prostatic Disease

• Lee YK
• Kim HS
• Oh TH

Abstract

PURPOSE: We assessed the influence of age and prostate volume on the serum total PSA and percent free PSA level, and total PSA on the percent free PSA level in men with benign prostatic disease except clinically detectable prostatic cancer.
MATERIALS AND METHODS
Sera were obtained from 250 men with total PSA level of 0 to 20 ng/ml who were clinically negative for cancer. Total and free PSA levels were measured using ELSA-PSA2 and FPSA-RIACT immunoradiometry assay. Prostate volume was determined by transrectal ultrasound.
RESULTS
Age and prostate volume correlated significantly with Total PSA levels (r=0.204 and 0.482, p<0.05) and free PSA levels (r=0.246 and 0.539, p<0.05) but not with percent free PSA(r=0.057 and -0.039, p=0.188 and 0.541). Total PSA levels correlated significantly with free PSA(r=0.853, p<0.05) and percent free PSA(r=-0.398, p<0.05).
CONCLUSIONS
Among men with total PSA levels of 0 to 20 ng/ml and do not have clinically detectable prostatic cancer, total PSA and free PSA increases with increasing age and prostate volume. And percent free PSA decreases with increasing total PSA but it was not influenced by age and prostate volume.

Keyword

Age; Volume; Total PSA; Percent free PSA

MeSH Terms

Humans
Male
Prostate*
Prostatic Diseases*
Prostatic Neoplasms
Ultrasonography