Korean J Thorac Cardiovasc Surg.  2010 Aug;43(4):381-386.

Analysis of Risk Factors and Effect of Vancomycin for Sternal Infection after Coronary Artery Bypass Graft

Affiliations
  • 1Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam University, Korea. tejung@med.yu.ac.kr

Abstract

BACKGROUND
Sternal wound infection (SWI) is an important complication after cardiac surgery. The aim of this study was to investigate the predictors affecting sternal wound infection and preventive factors including short term Vancomycin therapy in patients who underwent coronary artery bypass grafting (CABG). MATERIAL AND METHOD: A retrospective study was done using data collected from January 2001 through December 2007. This included 219 patients who had isolated CABG. The definition of SWI was documentation from a microbiological study and a requirement for simple closure or other surgical revision. RESULT: The overall incidence of SWI was 7.8% (n=17). The causative organisms were methicillin resistant Staphylococcus aureus (MRSA, n=13), methicillin resistant Staphylococcus epidermidis (n=2), Pseudomonas aeruginosa (n=1), and Candida albicans (n=1). Ten cases had deep sternal wound infection with mediastinitis; 7 cases had a superficial wound infection. Infection-related mortality was low (1/17; 6%). Diabetes mellitus (p=0.006) and smoking history (p=0.020) were factors that predicted high risk. Short term use of vancomycin decreased the incidence of MRSA-associated SWI (p=0.009). For treatment, curettage and rewiring or flap were needed in most cases (88%, n=14).
CONCLUSION
Patients who had diabetes mellitus and a smoking history need careful management. Short term use of vancomycin is effective for prevention of SWI with MRSA.

Keyword

Wound infection; Sternum; Coronary artery bypass

MeSH Terms

Candida albicans
Coronary Artery Bypass
Coronary Vessels
Curettage
Diabetes Mellitus
Humans
Incidence
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Pseudomonas aeruginosa
Reoperation
Retrospective Studies
Risk Factors
Smoke
Smoking
Staphylococcus aureus
Staphylococcus epidermidis
Sternum
Thoracic Surgery
Vancomycin
Wound Infection
Smoke
Vancomycin
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