J Gynecol Oncol.  2013 Jan;24(1):59-65. 10.3802/jgo.2013.24.1.59.

Establishment of a Korea HPV cohort study

• Lee WC
• Lee SY
• Koo YJ
• Kim TJ
• Hur SY
• Hong SR
• Kim SS
• Kee MK
• Rhee JE
• Lee JS
• Choi HS
• Cho CH
• Kim KT
• Park JS

• KMID: 2288562
• DOI: http://doi.org/10.3802/jgo.2013.24.1.59

Abstract

We have designed a five-year multicentre prospective cohort study in women who are both human papillomavirus (HPV)-positive with either atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) of cervix. This study aimed to analyze the risk of developing a high-grade squamous intraepithelial lesion (HSIL) from either ASCUS or LSIL in HPV-positive women, so called 'progression' rate, to investigate differences in the progression rates according to HPV type-specific infection, and to evaluate the various factors associated with the persistence or clearance of HPV infection in the Korean population. At present, the study protocol composed of cervical cytology, HPV DNA testing, and questionnaire have been conducted actively since the first participant was enrolled in 2010. This study is the first nationwide Korea HPV cohort study. Our data will provide valuable information about not only the ambiguous cytology results of ASCUS and LSIL but also the effect of the specific HPV type and other various factors on the progression to HSIL. Finally, the results of our study will be helpful and applicable to determine the primary cervical cancer prevention strategies.

Keyword

Cervical intraepithelial neoplasms; Cohort studies; Human papillomavirus; Uterine cervical neoplasms

MeSH Terms

Cervical Intraepithelial Neoplasia
Cervix Uteri
Cohort Studies
Female
Human Papillomavirus DNA Tests
Humans
Korea
Uterine Cervical Neoplasms
Surveys and Questionnaires

Figure

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  Fig. 1 Schematic flow chart for the screening and follow-up. Women will be examined by repeat cytology and HPV testing every 6 months. Compared with the previous results of the HPV testing, the next follow-up would yield four possible kinds of change in HPV infection type and the result of cytology will be categorized into two groups (

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