J Clin Neurol.  2008 Mar;4(1):51-57. 10.3988/jcn.2008.4.1.51.

Multiple Sclerosis and Peripheral Multifocal Demyelinating Neuropathies Occurring in a Same Patient

• Kwon JY
• Kim JY
• Jeong JH
• Park KD

• KMID: 2287687
• DOI: http://doi.org/10.3988/jcn.2008.4.1.51

Abstract

The co-occurrence of multiple sclerosis and peripheral demyelinating neuropathy is rare. It has been disputed whether these are pathologically related or coincidental findings. We report a 36-year-old woman who presented with diplopia, right facial palsy and left-sided weakness. Brain magnetic resonance imaging showed a lesion indicative of central demyelinating disease. Nerve conduction studies revealed peripheral multifocal demyelinating neuropathies. We suggest that the central and the peripheral lesions may be continua of a demyelinating process.

Keyword

Multiple sclerosis; Demyelinating neuropathy; Conduction block

MeSH Terms

Adult
Brain
Demyelinating Diseases
Diplopia
Facial Paralysis
Female
Humans
Magnetic Resonance Imaging
Multiple Sclerosis
Neural Conduction

Figure

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  Figure 1 Demyelinating pattern with conduction block and temporal dispersion in motor conduction studies of left median nerve (2006.04.24, before the treatment).

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  Figure 2 Brain MRI on first admission, (A) T2-weighted image showed a region of increased signal intensity in right cerebellopontine angle and (B) in gadolinium-enhanced image this lesion showed gadolinium-enhancement.

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  Figure 3 Pattern-reversal visual evoked potentials test shows prolonged P100 latency of right eye.

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  Figure 4 Brain MRI on third admission, (A) T2-weighted image shows a region of high signal intensity on left lateral medulla, and (B) Fat-suppression image shows a gadolinium-enhanced lesion in a prechiasmatic area of right optic nerve.

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