Korean J Psychopharmacol.  2003 Sep;14(3):206-214.

Clinical Characteristics and Short-term Treatment Response in Patients with Obsessive-Compulsive Disorder

• Kim CH
• Koo MS
• Suh HS
• Shin YS
• Kim JW
• Cheon KA
• Nam YY
• Lee HS

Abstract

OBJECTIVE
The aim of this study was to describe and evaluate the clinical data and short-term treatment response in patients with obsessive-compulsive disorder (OCD) based on an outpatient setting. METHODS: A group of patients with OCD underwent mean 12-weeks treatment with selective serotonin reuptake inhibitors. The patients were divided into two groups according to treatment response, defined as a reduction of the Yale-Brown Obsessive Compulsive Scale total score >35% and CGI of 1 or 2. RESULTS: 1) Among the 249 patients, 24.1% had checking type and 23.7% washing type. Among these two types, 31.9% had mood disorder, 15.0% had anxiety disorder and 24.5% personality disorder as co-morbidity. One hundred fourteen patients (45.8%) responded to the treatment and 135 (54.2%) did not. The responders decreased Y-BOCS scores from 27.9+/-7.2 at baseline to 21.3+/-6.4 and 19.3+/-3.8 at post-treatment 8 and 12 weeks, respectively (repeated measure ANOVA, p=0.039). There were no differences among the treatment responses to serotonin reuptake inhibitors. CONCLUSION: About half of the OCD patients showed a response to pharmacological treatment using SSRI in the outpatient clinic setting for 12 weeks. Long-term and contrast studies of OCD may elucidate further clinical aspects of this disorder in the future.

Keyword

Obsessive compulsive disorder; Clinical courses; Subtype; Comorbidity; Short term response

MeSH Terms

Ambulatory Care Facilities
Anxiety Disorders
Comorbidity
Humans
Mood Disorders
Obsessive-Compulsive Disorder*
Outpatients
Personality Disorders
Serotonin Uptake Inhibitors
Serotonin Uptake Inhibitors