J Breast Cancer.  2012 Mar;15(1):124-127. 10.4048/jbc.2012.15.1.124.

Primary Leiomyosarcoma of the Breast: A Case Report

• Karabulut
• Akkaya H
• Moray G

• KMID: 2286484
• DOI: http://doi.org/10.4048/jbc.2012.15.1.124

Abstract

Primary leiomyosarcoma of the breast is an extremely rare tumor, accounting for less than 1% of all breast tumors and only 24 cases have been reported in the English medical journals. It is quite difficult to diagnose leiomyosarcoma preoperatively. Establishing an accurate diagnosis is very important in planning treatment. When preoperative diagnosis can be achieved before or during the operation, wide resection should be performed. There is no need for axillary lymph node dissection. In this case report, we present a case involving primary leiomysarcoma of the breast in a 48-year-old woman and we discuss optimal treatment options.

Keyword

Breast; Leiomyosarcoma; Mastectomy

MeSH Terms

Accounting
Breast
Breast Neoplasms
Female
Humans
Leiomyosarcoma
Lymph Node Excision
Mastectomy
Middle Aged

Figure

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  Figure 1 Preoperative mammogram. (A) A 8×6 cm well-circumscribed tumor mass is located in the upper and lower outer quadrants of the right breast. (B) The left breast is normal.

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  Figure 2 Macroscopically, a lobulated elastic tumor that was, 10×9×6 cm in size was totally excised.

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  Figure 3 Histopathology of leiomyosarcoma. Immunostaining for smooth muscle actin (SMA) was positive in the malign spindle cells (SMA, ×200).

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  Figure 4 Spindle shaped tumour cells and mitosis (H&E stain, ×200).

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  Figure 5 Smooth muscle actin (+) spindle tumour cells (×400).

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