J Breast Cancer.
2012 Dec;15(4):427-433. 10.4048/jbc.2012.15.4.427.
Body Mass Index Is Not Associated with Treatment Outcomes of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy: Korean Data
- Affiliations
-
- 1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. moisa@snu.ac.kr
- 2Cancer Research Institute, Seoul National University, Seoul, Korea.
- 3Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- 4Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
- 5Department of Molecular Medicine & Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
- 6Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2286440
- DOI: http://doi.org/10.4048/jbc.2012.15.4.427
Abstract
- PURPOSE
The effects of body mass index on pathologic complete response and survival have not been reported in Korean patients with breast cancer. The purpose of this study was to evaluate the predictive or prognostic value of obesity in breast cancer receiving neoadjuvant chemotherapy.
METHODS
A total of 438 stage II or III breast cancer patients treated with neoadjuvant chemotherapy were enrolled and analyzed retrospectively.
RESULTS
In the study, 319 patients (72.8%) were normal weight, 100 patients (22.8%) were overweight, and 19 patients (4.3%) were obese. Baseline clinicopathologic characteristics were not different among the groups, except for age. There were no differences in pathologic complete response rate between the groups (9.7% in normal weight, 10.0% in overweight, 5.3% in obese; p=0.804). Neither overweight nor obese patients showed a significant difference in relapse-free survival compared to normal weight patients (p=0.523 and p=0.931, respectively). Also, no significant difference in overall survival (p=0.520 and p=0.864, respectively) was observed.
CONCLUSION
Obesity or higher body mass index was not significantly associated with pathologic complete response and survival in Korean patients with breast cancer who received neoadjuvant chemotherapy. Our results suggest that the prognostic impact of body mass index is different from that of Western patients.
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