Clinical Significance of Serum C-Reactive Protein in Patients with Colorectal Cancer

Park, Sung Chul; Jeen, Yoon Tae; Lee, Kwang Gyun; Kim, Juhyung; Hyun, Jong Jin; Kim, Eun Sun; Park, Sanghoon; Keum, Bora; Seo, Yeon Seok; Kim, Yong Sik; Chun, Hoon Jai; Um, Soon Ho; Choi, Jai Hyun; Kim, Chang Duck; Ryu, Ho Sang

Abstract

BACKGROUND/AIMS
C-reactive protein (CRP) is a general marker of inflammation and increased CRP level is reported in several cancers. It has been reported that CRP is an independent factor predicting survival in colorectal cancer patients, although this claim is still under debate. The aim of this study was to investigate the association between CRP and the characteristics of colorectal cancer patients.
METHODS
One hundred eighty-four patients diagnosed with colorectal cancer between January 2007 and January 2009 were included. The patients with active infectious diseases, other tumors, cardiovascular disease, or inflammatory bowel disease were excluded. The CRP levels of colorectal cancer patients were compared with the control group comprised of 175 healthy adults with a normal colonoscopy.
RESULTS
The median CRP in the colorectal cancer patients (3.36 mg/L) was higher than the control group (0.48 mg/L). There was a significant correlation between CRP and the stage of colorectal cancer (p<0.001). CRP was increased significantly in Dukes' stage D. CRP had a significant correlations with the CEA and CA 19-9 levels, the ESR, and the white blood cell count, and an inverse correlation with albumin. The CRP level in colon cancer patients was higher than rectal cancer patients (p=0.032). There were no significant difference in the CRP according to metastatic sites, such as the liver and peritoneum.
CONCLUSIONS
Serum CRP levels were higher in patients with colorectal cancer and high CRP level is a predictor of advanced disease.