Gut Liver.  2010 Jun;4(2):186-191.

Efficacy and Safety of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients with Comorbid Diseases

• Kim BJ
• Chang TH
• Kim JJ
• Min BH
• Lee JH
• Son HJ
• Rhee PL
• Rhee JC
• Kim KM
• Park CK

Abstract

BACKGROUND/AIMS
Endoscopic submucosal dissection (ESD), a new and potentially curative method for treating gastrointestinal neoplasms, may have longer procedure time and the risk of complications when compared to conventional endoscopic mucosal resection. This study evaluated the efficacy and safety of ESD in patients with comorbid diseases.
METHODS
The outcomes of 337 patients who underwent ESD for early gastric cancer at Samsung Medical Center from April 2003 to December 2006 were analyzed retrospectively. The Charlson comorbidity scale was used to divide the patients into low-risk (no risk factor) and high-risk (at least one risk factor) groups. The outcomes and complications were compared between the high- and low-risk groups.
RESULTS
The low- and high-risk groups comprised 240 and 97 patients with mean ages of 61.1 and 64.7 years, respectively (p=0.002). Tumor location, tumor size, depth of invasion, procedure duration, and rates of en bloc resection, complete resection, complication, and recurrence did not differ significantly between the two groups (p>0.05).
CONCLUSIONS
ESD may be a safe and effective treatment for early gastric cancer in patients with comorbid diseases.

Keyword

Early gastric cancer; Endoscopic submucosal dissection; Comorbid disease; Complication

MeSH Terms

Comorbidity
Gastrointestinal Neoplasms
Humans
Recurrence
Retrospective Studies
Stomach Neoplasms