Korean J Perinatol.  1997 Dec;8(4):408-413.

Chromosime Analysis from Chorionic Villi Samples in Recurrent Sponataneous Abortion

Abstract

Recurrent abortion has been defined as the occurrence of three or more clinically recognized pregnancy loss before 20 weeks and it occurs in 1% of women. The chromosomal abnormalities of abortuses have been suggested as the most common causes of recurrent abortion. We have studied the incidence of chromosomal abnormalities in 57 patients with recurrent abortion using the chorionic villi samples. Of the 57 abortuses analysed, 32 (56.1%) had chromosomal abnormalities. Trisomy was predominant (23 cases, 40.4%), followed by mosaicism 3 (5.2%), tetraploidy 2 (3.5%), monosomy 2 (3.5%), and structural anomaly 1 (1.8%). Trisomy for the chromosome 16 was most prevalent among trisomies. The incidence of trisomy was positively related to matemal age above 35 year-old. But there is not statistically significant. And there are no correlation between gestational age and chromosomal abnormalities. In conclusion, the incidence of chromosomal abnormalities of recurrent abortuses was 56.1% which was similar to that of the other reports. This means that the analysis of karyotype of chorionic villi, as the first test to investigate the cause of recurrent abortion, may be not useful, however, it will require further.

Keyword

Karyotype; Conceptus; Chorionic villi sampling; Recurrent abortion

MeSH Terms

Abortion, Habitual
Adult
Chorion*
Chorionic Villi Sampling
Chorionic Villi*
Chromosome Aberrations
Chromosomes, Human, Pair 16
Female
Gestational Age
Humans
Incidence
Karyotype
Monosomy
Mosaicism
Pregnancy
Tetraploidy
Trisomy
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