Clin Nutr Res.  2015 Apr;4(2):97-103. 10.7762/cnr.2015.4.2.97.

Glycated Hemoglobin is a Better Predictor than Fasting Glucose for Cardiometabolic Risk in Non-diabetic Korean Women

• Yoon SR
• Lee JH
• Na GY
• Seo YJ
• Han S
• Shin MJ
• Kim OY

• KMID: 2279355
• DOI: http://doi.org/10.7762/cnr.2015.4.2.97

Abstract

This study aimed to investigate if glycated hemoglobin (HgbA1C) as compared to fasting blood glucose is better for reflecting cardiometabolic risk in non-diabetic Korean women. Fasting glucose, HgbA1C and lipid profiles were measured in non-diabetic women without disease (n = 91). The relationships of fasting glucose or HgbA1C with anthropometric parameters, lipid profiles, and liver and kidney functions were analyzed. Both fasting glucose and HgbA1C were negatively correlated with HDL-cholesterol (r = -0.287, p = 0.006; r = -0.261, p = 0.012), and positively correlated with age (r = 0.202, p = 0.008; r = 0.221, p = 0.035), waist circumference (r = 0.296, p = 0.005; r = 0.304, p = 0.004), diastolic blood pressure (DBP) (r = 0.206, p = 0.050; r = 0.225, p = 0.032), aspartate transaminase (AST) (r = 0.237, p = 0.024; r = 0.368, p < 0.0001), alanine transaminase (ALT) (r = 0.296, p = 0.004; r = 0.356, p = 0.001), lipid profiles including triglyceride (r = 0.372, p < 0.001; r = 0.208, p = 0.008), LDL-cholesterol (r = 0.315, p = 0.002; r = 0.373, p < 0.0001) and total cholesterol (r = 0.310, p = 0.003; r = 0.284, p = 0.006). When adjusted for age and body mass index, significant relationships of DBP (r = 0.190, p = 0.049), AST (r = 0.262, p = 0.018), ALT (r = 0.277, p = 0.012), and HDL-cholesterol (r = -0.202, p = 0.049) with HgbA1C were still retained, but those with fasting glucose disappeared. In addition, the adjusted relationships of LDL-cholesterol and total cholesterol with HgbA1C were much greater than those with fasting glucose. These results suggest that glycated hemoglobin may be a better predictor than fasting glucose for cardiometabolic risk in non-diabetic Korean women.

Keyword

Glycated hemoglobin; Fasting glucose; Lipid profile; Cardiometabolic risk

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Blood Glucose
Blood Pressure
Body Mass Index
Cholesterol
Fasting*
Female
Glucose*
Hemoglobin A, Glycosylated*
Humans
Kidney
Liver
Triglycerides
Waist Circumference
Alanine Transaminase
Aspartate Aminotransferases
Blood Glucose
Cholesterol
Glucose

Figure

• 

  Figure 1 Relationships of blood pressure and liver function markers with fasting glucose or glycated Hemoglobin (HgbA1C) tested by Spearsman and partial correlation analysis, ø: log-transformed r0: correlation coefficient (unadjusted), r1: correlation coefficient (adjusted for age and body mass index); (A) presents corrleation between diastolic BP and fasting glucose or HgbA1C, (B) presents corrleation between AST and fasting glucose or HgbA1C, and (C) presents corrleation between ALT and fasting glucose or HgbA1C; AST: aspartate aminotransferase, ALT: alanine aminotransferase, BP: blood pressure.

• 

  Figure 2 Relationships of serum fasting lipid profiles with fasting glucose or glycated hemoglobin (HgbA1C) tested by Pearson and partial correlation analysis, ø: log-transformed r0: correlation coefficient (unadjusted), r1: correlation coefficient (adjusted for age and body mass index); (A) presents corrleation between triglyceride and fasting glucose or HgbA1C, (B) presents corrleation between total cholesterol and fasting glucose or HgbA1C, (C) presents corrleation between LDL-cholesterol and fasting glucose or HgbA1C, and (D) presents corrleation between HDL-cholesterol and fasting glucose or HgbA1C.

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