Korean J Pediatr Infect Dis.  2011 Dec;18(2):135-142.

Pattern of Hospital-Associated Infections in Children Admitted in the Intensive Care Unit of a University Hospital

• Kim SN
• Won CB
• Cho HJ
• Eun BW
• Sim SY
• Choi DY
• Sun YH
• Cho KH
• Son DW
• Tchah H
• Jeon IS

Abstract

PURPOSE
Hospital associated infection (HAI) caused by multidrug-resistant (MDR) microorganisms has been recognized as an important issue in the world, especially in critically ill patients such as the patients admitted in the intensive care unit. There are fewer papers about MDR-HAI in pediatric patients compared to adult patients. In this study, we investigated the incidence and associated factors of MDR-HAI in children admitted to the intensive care unit (ICU) of a university hospital.
METHODS
We retrospectively evaluated 135 children who were admitted in ICU for at least 3 days between January 2009 and December 2010. HAI cases were divided into MDR-HAI group and non-MDR-HAI group. Clinical characteristics and various associated factors were compared between those groups.
RESULTS
In 39 patients, 45 cases of ICU-related HAI were developed. ICU-related HAI incidence was 47.7 per 1000 patient-days. Thirty-six cases (80.0%) were MDR-HAI. Acinetobacter baumannii was isolated more commonly in MDR-HAI group. And the followings were found more frequently in MDR-HAI group than non-MDR-HAI group: medical condition as an indication for ICU admission, mechanical ventilation, urinary catheterization and previous use of broad-spectrum antibiotics. Among the risk factors, previous use of broad-spectrum antibiotics was the independent risk factor for MDR-HAI.
CONCLUSION
ICU-related HAI incidence was higher than previously reported. Previous use of broad-spectrum antibiotics was the independent risk factor for MDR-HAI. To investigate the characteristics of MDR-HAI in children admitted in ICU, further studies with a larger sample size over a longer period of time are warranted.

Keyword

Multidrug-resistant; Hospital-associated infection; Intensive care unit; Risk factor

MeSH Terms

Acinetobacter baumannii
Adult
Anti-Bacterial Agents
Child
Critical Illness
Humans
Incidence
Critical Care
Intensive Care Units
Respiration, Artificial
Retrospective Studies
Risk Factors
Sample Size
Urinary Catheterization
Urinary Catheters
Anti-Bacterial Agents

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