Korean J Pathol.  2006 Jun;40(3):241-244.

Juvenile Xanthogranuloma of the Nasal Cavity: A Case Report and Review of the Literature

• An JS
• Han SH
• Lee JH
• Lee ES
• Park HR
• Kim YS

Abstract

Juvenile xanthogranuloma (JXG) is a benign and self-limiting non-Langerhans-cell histiocytosis that generally occurs during infancy and childhood. It develops frequently in the head and neck but is very rare in the nasal cavity. To date, only five cases of JXG in the nasal cavity have been reported. Here, we report the second case of JXG in the nasal cavity in Korea. A 19-year-old male patient presented with a protruding 1.1 cm mass in the left nasal vestibule. Histologically, a dense dermal infiltrate of histiocytes with Touton giant cells was observed. Immunohistochemically, the histiocytes tested positive for CD68 and the S-100 protein but negative for CD1a. This shows that a S-100-positive histiocytic lesion dose not exclude a diagnosis of JXG.

Keyword

Juvenile xanthogranuloma; Nasal cavity; Langerhans-cell histiocytosis

MeSH Terms

Diagnosis
Giant Cells
Head
Histiocytes
Histiocytosis, Langerhans-Cell
Histiocytosis, Non-Langerhans-Cell
Humans
Korea
Male
Nasal Cavity*
Neck
S100 Proteins
Xanthogranuloma, Juvenile*
Young Adult
S100 Proteins