Korean J Pathol.  2006 Aug;40(4):269-273.

Pathological Findings of Crohn's Disease in the Stomach

• Yoo C
• Lee BI
• Choi KY
• Maeng LS
• Lee A
• Kang CS
• Kwon GY
• Kim KM
• Park CK

Abstract

BACKGROUND: The incidence of Crohn's disease in the upper digestive tract, and especially in the stomach, is recently increasing. Focal inflammatory reaction without Helicobacter pylori (H. pylori) infection is thought to be the characteristic pathologic findings suggesting Crohn's disease in the stomach. Yet gastric involvement of Crohn's disease has not been studied in Korea. We studied the endoscopic and pathologic findings of patients with Crohn's disease in the stomach by taking biopsies.
METHODS
Thirty patients with Crohn's disease who underwent gastroduodenoscopy followed by biopsies were included in the study. The pathology of the gastric biopsy specimens and the presence of H. pylori were evaluated.
RESULTS
Among 30 cases, 22 cases (73.3%) were H. pylori negative and 8 cases (26.7%) were H. pylori positive. For the H. pylori negative cases, all but one cases showed pit abscess and focal lymphocytic collections in the antrum. Granulomas were found in 6 cases (20%) and they were exclusively located in the antrum.
CONCLUSIONS
In the stomach, pit abscess and focal lymphocytic collections that are not associated with H. pylori infection are the characteristic pathologic findings found in Crohn's disease.

Keyword

Crohn's disease; Lymphocytes collection; Granuloma; Helicobacter pylori

MeSH Terms

Abscess
Biopsy
Crohn Disease*
Gastrointestinal Tract
Granuloma
Helicobacter pylori
Humans
Incidence
Korea
Pathology
Stomach*