Korean J Otorhinolaryngol-Head Neck Surg.  2012 Nov;55(11):736-739. 10.3342/kjorl-hns.2012.55.11.736.

A Case of Spontaneous Resolution of Castleman's Disease in the Neck

• Yun SH
• Chae SR
• Yoo DJ
• Joo YH

• KMID: 2277433
• DOI: http://doi.org/10.3342/kjorl-hns.2012.55.11.736

Abstract

Castleman's disease, or angiofollicular lymph node hyperplasia, is a rare disorder that involves the proliferation of lymphoid tissue. The disease entity is classified into three pathologic subtypes, namely, the hyaline vascular, plasma cell, and mixed types; however, clinically, they are classified as unicentric and multicentric types. The former is treated primarily by excision, whereas systemic therapies have been used to treat the latter form, because of its more aggressive pattern. We report a case of a 17-year-old woman who underwent an excisional biopsy of one of the multiple affected cervical lymph nodes. A subsequent histopathologic examination revealed hyaline vascular Castleman's disease. One month later, the disease spontaneously regressed and no recurrence was observed over a 12-month period following the excisional biopsy.

Keyword

Lymphoproliferative disorders; Neck; Spontaneous remission

MeSH Terms

Adolescent
Biopsy
Female
Giant Lymph Node Hyperplasia
Humans
Hyalin
Lymph Nodes
Lymphoid Tissue
Lymphoproliferative Disorders
Neck
Plasma Cells
Recurrence
Remission, Spontaneous