Korean J Otorhinolaryngol-Head Neck Surg.
2012 Jun;55(6):364-368. 10.3342/kjorl-hns.2012.55.6.364.
Value of 18F-Fluorodeoxyglucose Position Emission Tomography/Computed Tomography in Diagnosis of Cervical Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma: Comparison with Computed Tomography and Magnetic Resonance Imaging
- Affiliations
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- 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Korea. kytae@hanyang.ac.kr
- 2Department of Nuclear Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- 3Department of Radiology, College of Medicine, Hanyang University, Seoul, Korea.
- KMID: 2277361
- DOI: http://doi.org/10.3342/kjorl-hns.2012.55.6.364
Abstract
- BACKGROUND AND OBJECTIVES
Cervical lymph node metastasis is a very important prognostic factor of head and neck squamous cell carcinoma (HNSCC). Therefore, strict evaluation of cervical lymph node metastasis is necessary for accurate staging and proper treatment planning. This study compares computed tomography (CT) and magnetic resonance imaging (MRI) to position emission tomography-computed tomography (PET-CT), and evaluates the clinical role of PET-CT in the diagnosis of cervical metastasis of HNSCC.
SUBJECTS AND METHOD
From October 2004 to September 2010, we studied 74 patients with HNSCC who underwent PET-CT, CT and MRI before undergoing neck dissection for the treatment of cervical lymph node metastasis. We compared pathologic results of 374 cervical lymph node levels in 74 patients with results of PET-CT, CT and MRI. We analyzed and compared sensitivity, specificity, predictability and accuracy of the three imaging methods.
RESULTS
Among the 74 patients, 49 (66.2%) patients had positive cervical lymph node metastasis. Of the 374 cervical lymph node levels, 86 levels were confirmed to be positive lymph node metastasis. Sensitivity and specificity of PET-CT was 87.4% and 94.8% when the cut-off value of SUVmax was 1.855. Sensitivity, specificity, positive and negative predictive value and accuracy of PET-CT were higher than those of CT or MRI.
CONCLUSION
PET-CT is more effective than CT or MRI in the diagnosis of cervical lymph node metastasis of HNSCC.
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