Korean J Otolaryngol-Head Neck Surg.  2001 Nov;44(11):1231-1234.

A Case of Adenosqumous Carcinoma Ex Pleomorphic Adenoma of Hard Palate

• Kim YM
• Cho JI
• Lee SJ
• Kim JM

Abstract

Carcinoma ex pleomorphic adenoma is a carcinoma that shows histologic evidence of arising in or from a preexisting benign mixed tumor. We experienced a case of carcinoma ex pleomorphic adenoma arising in the hard palate with neck metastatasis. The patient was 48-year-old male presenting ovoid elevated palatal mass that has been present for 25 years and rapid growing left neck mass for 3 months. The overlying mucosal surface was ulcerated. The tumor was well marginated but focally tightly adherent to the adjacent tissue. The initial pathologic diagnosis of open biopsy specimen was invasive squamous cell carcinoma. After the total removal, the histologic examination revealed that the tumor was composed of adenosquamous carcinoma and benign pleomorphic adenoma. The adenosquamous carcinoma, where grandular and epithelial differentiation were seen in the same clump of cells, showed extensive stromal hyalinization with necrosis and calcification. The metastatic neck lesion showed only squamous cell carcinoma component without adenocarcinoma. We present a case of an unusual carcinoma ex pleomorphic adenoma with adenosquamous cell carcinoma in the hard palate and neck metastasis.

Keyword

Adenosquamous carcinoma; Hard palate

MeSH Terms

Adenocarcinoma
Adenoma, Pleomorphic*
Biopsy
Carcinoma, Adenosquamous
Carcinoma, Squamous Cell
Diagnosis
Humans
Hyalin
Male
Middle Aged
Neck
Necrosis
Neoplasm Metastasis
Palate, Hard*
Ulcer