Korean J Otolaryngol-Head Neck Surg.  2001 Aug;44(8):800-804.

Influence of Incudomalleolar joint and Hearing in rats dosed with Ciprofloxacin

Affiliations
  • 1Department of Otolaryngology, 2Anatomy, College of Medicine Konkuk University, Chungju, Korea.

Abstract

BACKGROUND AND OBJECTIVES: Quinolone-induced arthropathy is an unusual toxic effect observed in juvenile animals of multiple species. Such toxic effects are usually found in joint cartilages. The reports of chondrotoxic potential of quinolones in juvenile animals were mainly performed in weight bearing joints such as hips and knees. The purpose of this study was to investigate the morphological changes in the incudomalleolar joint of immature rats dosed with ciprofloxacin, and to draw relationship between the incudomalleolar joint pathology and hearing.
MATERIALS AND METHODS
An experimental group of 21-day-old rats were administrated intraperitoneally with 200 mg ciprofloxacin/kg for 10 days. The hearing threshs of the control and experimental animals were determined with auditory brainstem response (ABR). Their ossicles were obtained and fixed, and we observed them with light microscopy (LM) and transmission electron microscopy (TEM).
RESULTS
The ABR threshs were increased in the ciprofloxacin administrated group, and the increased latency of the first waves were identified in the ciprofloxacin administrated group, but there were no differences in the interval of wave I-III. The LM findings of incudomalleolar joint in the ciprofloxacin administrated group showed cartilage lesions such as disrupted articilar surface, irregular cellularity of the chondrocytes, matrix swelling, cleft formation, decreased matrix staining. The TEM findings of the incudomalleolar joint cartilage in the ciprofloxacin administrated group showed decreased bundle-like matrix and cell process, condensed nucleus, and vacuolated cytoplasm.
CONCLUSION
From the results of recent works and the present study, we suggest that ciprofloxacin may induce morphological changes in the incudomalleolar joint, and that such morphological changes may induce conductive hearing loss.

Keyword

Ciprofloxacin; Incudomalleolar joint; Conductive hearing loss

MeSH Terms

Animals
Cartilage
Chondrocytes
Ciprofloxacin*
Cytoplasm
Evoked Potentials, Auditory, Brain Stem
Hearing Loss, Conductive
Hearing*
Hip
Joints*
Knee
Microscopy
Microscopy, Electron, Transmission
Pathology
Quinolones
Rats*
Weight-Bearing
Ciprofloxacin
Quinolones
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