Korean J Pathol.  1986 Sep;20(3):374-377.

Endometrial Carcinoma Associated with Stein-Leventhal Syndrome: Two cases report

• Kim HY
• Kim I
• Park HR
• Lee KN
• Paik SY

Abstract

Stein-Leventhal syndrome is a clinicopathological entity characterized by chronic anovulation and sclerotic ovaries. Clinically, the affected patients typically present their third decade with a history of premenarchal obesity and postmenarchal onset of oligomenorrhea or amenorrhea, infertility, and clinical evidence of increased androgen production. In some patients, there are estrogenic phenomena such as menometrorrhagia with or without endometrial hyperplasia or carcinoma. Several studies have indicated that there may be an increased incidence of ovarian neoplasia in polycystic ovaries. Recently, we experienced two cases of polycystic ovaries assotiated with endometrial carcinoma in premenopausal women, who had clinical characteristics of Stein-Leventhal syndrome; one of the cases had additional serous cystandenofibroma.

MeSH Terms

Amenorrhea
Anovulation
Endometrial Hyperplasia
Endometrial Neoplasms*
Estrogens
Female
Humans
Incidence
Infertility
Obesity
Oligomenorrhea
Ovary
Polycystic Ovary Syndrome*
Estrogens