Korean J Obstet Gynecol.  2011 Nov;54(11):707-711. 10.5468/KJOG.2011.54.11.707.

A case of embryonal rhabdomyosarcoma of the uterine cervix in a middle-aged woman

• Shim AR
• Lee M
• Paek JH
• Kim MJ
• Kim SW

• KMID: 2274111
• DOI: http://doi.org/10.5468/KJOG.2011.54.11.707

Abstract

Embryonal rhabdomyosarcoma (RMS) of the cervix is rare and most commonly occurs in the late teens and early 20s. We report a case of cervical embryonal RMS in a 52-year-old woman. This patient presented with an abnormal vaginal bleeding for 2 months and a mass protruding from the introitus, measuring 7 x 6 cm. She underwent radical abdominal hysterectomy with bilateral pelvic lymph node dissection and radical vaginectomy. The final pathologic result was cervical RMS, consistent with the Intergroup RMS study group IIC. Immunohistochemistry was positive for desmin, myogenin, and myogenic diffentiation 1. The patient received conservative management in a convalescent hospital without adjuvant treatment due to cerebral hemorrhage and relapsed septic condition after surgery.

Keyword

Embryonal rhabdomyosarcoma; Uterine cervix

MeSH Terms

Adolescent
Cerebral Hemorrhage
Cervix Uteri
Desmin
Female
Hospitals, Convalescent
Humans
Hysterectomy
Immunohistochemistry
Lymph Node Excision
Middle Aged
Myogenin
Rhabdomyosarcoma, Embryonal
Uterine Hemorrhage
Desmin
Myogenin

Figure

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  Fig. 1 A 7 × 6 cm size soft pinkish irregular mass arising from the uterine cervix and reaching up to the introitus.

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  Fig. 2 F-18 flurodeoxyglucose (FDG) positron emission tomography/ computed tomography finding. There was intense uptake in the protruding vaginal mass, consistent with malignancy. FDG uptake extension to the cervix area was seen, suggestive of malignant involvement and periregional infiltration was suspected.

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  Fig. 3 Gross finding after surgery.

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  Fig. 4 (A) The tumor consists of oval to spindle shaped malignant embryonal rhabdomyoblasts with eosinophilic cytoplasm (H&E, ×200). (B) The desmin immunoreactivity confirms the myoblastic differentiation (×100).

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