Korean J Obstet Gynecol.  2011 Jun;54(6):330-333. 10.5468/KJOG.2011.54.6.330.

Angiomyofibroblastoma of the uterine cervix in a breast cancer patient: A case report

Affiliations
  • 1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 2Department of Pathology, Jeju National University School of Medicine, Jeju, Korea.
  • 3Department of Obstetrics and Gynecology, Jeju National University School of Medicine, Jeju, Korea. kimsy@cheju.ac.kr

Abstract

Angiomyofibroblastoma (AMFB) is a rare mesenchymal tumor mostly involving the female lower genital tract. Although a large number of cases of vulva and vagina has been reported, a report on a case of the uterine cervix is uncommon. Despite unknown pathogenesis of AMFB, positive immunoreactivity for hormonal receptor of AMFB allows to make an assumption that the hormonal stimuli may have a role on the development of AMFB. Therefore, it is potential that estrogenic effect of tamoxifen gives stimuli on hormonally responsible mesenchymal cells, resulting in AMFB. We report a case of AMFB of the uterine cervix in a breast cancer patient with prolonged tamoxifen treatment with brief literature review.

Keyword

Angiomyofibroblastoma; Cervix uteri; Breast neoplasm; Tamoxifen

MeSH Terms

Breast
Breast Neoplasms
Cervix Uteri
Estrogens
Female
Humans
Tamoxifen
Vagina
Vulva
Estrogens
Tamoxifen

Figure

  • Fig. 1 A mobile, rubbery, 3 cm sized mass which initially diagnosed as a cervical myoma.

  • Fig. 2 Microscopic appearance of the angiomyofibroblastoma shows spindle or oval shaped tumor cells arranged around thin-walled blood vessels (H&E, ×200).

  • Fig. 3 Diffuse positive staining of stromal tumor cells for the estrogen receptor (×200).

  • Fig. 4 Strong immunoreactivity of stromal tumor cells for desmin (×200).


Reference

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