Korean J Obstet Gynecol.  2010 Apr;53(4):365-370. 10.5468/kjog.2010.53.4.365.

Serous adenocarcinoma arising from ovarian endometriosis after menopause

• Kim TH
• Lee HH
• Chung SH
• Kwak JJ
• Lee BI
• Hong YP

• KMID: 2273865
• DOI: http://doi.org/10.5468/kjog.2010.53.4.365

Abstract

Endometriosis is estrogen dependent disease in reproductive age. Endometriosis is a chronic inflammatory gynecologic disease. Problems associated with endometriosis include dysmenorrhea, dyspareunia, and infertility. Postmenopausal endometriosis is rare. Also, malignant transformation in endometriosis is rare. There is no report in Korea about serous adenocarcinoma arising from endometriosis after menopause. The authors present a case of serous adenocarcinoma arising from endometriosis after menopause with brief review of the literature.

Keyword

Serous adenocarcinoma; Endometriosis; Menopause

MeSH Terms

Adenocarcinoma
Dysmenorrhea
Dyspareunia
Endometriosis
Estrogens
Female
Genital Diseases, Female
Infertility
Korea
Menopause
Estrogens

Figure

• 

  Fig. 1 Contrast-enhanced CT images show 7 cm sized low density mass in right side aspect of uterus.

• 

  Fig. 2 Laparoscopic finding shows right side severe adhesion and loculated cystic mass in pelvis.

• 

  Fig. 3 Pathologic findings. (A) Sections show cystic space lined by endometrial glandular cell and hemorrhage (H&E stain, ×40). (B) Low power view of tumor show closely packed papillae with fibrous core (H&E stain, ×40). (C) Immunohistochemical stain of cytokeratin 7 reveal diffuse strong reactivity (×100). (D) CD 10 immunostaining reveal reactivity.

Reference

1. Oxholm D, Knudsen UB, Kryger-Baggesen N, Ravn P. Postmenopausal endometriosis. Acta Obstet Gynecol Scand. 2007. 86:1–7.

2. Van Gorp T, Amant F, Neven P, Vergote I, Moerman P. Endometriosis and the development of malignant tumours of the pelvis: a review of literature. Best Pract Res Clin Obstet Gynaecol. 2004. 18:349–371.

3. Sainz de la Cuesta R, Eichhorn JH, Rice LW, Fuller AF Jr, Nikrui N, Goff BA. Histologic transformation of benign endometriosis to early epithelial ovarian cancer. Gynecol Oncol. 1996. 60:238–244.

4. Kawaguchi R, Tsuji Y, Haruta S, Kanayama S, Sakata M, Yamada Y, et al. Clinicopathologic features of ovarian cancer in patients with ovarian endometrioma. J Obstet Gynaecol Res. 2008. 34:872–877.

5. Yoshikawa H, Jimbo H, Okada S, Matsumoto K, Onda T, Yasugi T, et al. Prevalence of endometriosis in ovarian cancer. Gynecol Obstet Invest. 2000. 50:Suppl 1. 11–17.

6. Modesitt SC, Tortolero-Luna G, Robinson JB, Gershenson DM, Wolf JK. Ovarian and extraovarian endometriosis-associated cancer. Obstet Gynecol. 2002. 100:788–795.

7. Hirabayashi K, Yasuda M, Osamura RY, Hirasawa T, Murakami M. Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with endometriosis. Gynecol Oncol. 2006. 102:111–117.

8. Sampson MM. Conditions of validity of macallum's microchemical test for calcium. Science. 1925. 62:400–401.

9. Scott RB. Malignant changes in endometriosis. Obstet Gynecol. 1953. 2:283–289.

10. Nezhat F, Datta MS, Hanson V, Pejovic T, Nezhat C. The relationship of endometriosis and ovarian malignancy: a review. Fertil Steril. 2008. 90:1559–1570.

11. Kobayashi H, Sumimoto K, Moniwa N, Imai M, Takakura K, Kuromaki T, et al. Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan. Int J Gynecol Cancer. 2007. 17:37–43.

12. Kobayashi H, Sumimoto K, Kitanaka T, Yamada Y, Sado T, Sakata M, et al. Ovarian endometrioma: risks factors of ovarian cancer development. Eur J Obstet Gynecol Reprod Biol. 2008. 138:187–193.

13. Melin A, Sparen P, Persson I, Bergqvist A. Endometriosis and the risk of cancer with special emphasis on ovarian cancer. Hum Reprod. 2006. 21:1237–1242.

14. Olson JE, Cerhan JR, Janney CA, Anderson KE, Vachon CM, Sellers TA. Postmenopausal cancer risk after self-reported endometriosis diagnosis in the Iowa Women's Health Study. Cancer. 2002. 94:1612–1618.

15. Oral E, Ilvan S, Tustas E, Korbeyli B, Bese T, Demirkiran F, et al. Prevalence of endometriosis in malignant epithelial ovary tumours. Eur J Obstet Gynecol Reprod Biol. 2003. 109:97–101.

16. Kobayashi H. Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis. Int J Clin Oncol. 2009. 14:378–382.