The effect of body mass index of on the outcome of in vitro fertilization and embryo transfer in patients with polycystic ovary syndrome

Jeon, Gyun Ho; Kim, Chung Hoon; Kim, Eu Gene; Kim, So Ra; Kim, Sung Hoon; Chae, Hee Dong; Kang, Byung Moon

Abstract

OBJECTIVE
This study was performed to evaluate the effect of body mass index (BMI) on the outcome of in vitro fertilization and embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS).
METHODS
Ninety-six patients with PCOS who completed their first cycle of IVF-ET were included in this retrospective study. All patients were stimulated by GnRH antagonist multi-dose protocol. The patients were divided into one of two groups on the basis of BMI > or =23 kg/m2 vs. BMI <23 kg/m2, and their outcome of IVF-ET was compared. Additionally the patients with BMI > or =23kg/m2 were divided into patient group with 23 < or =BMI <25 kg/m2 and patient group with BMI > or =25 kg/m2, and these three groups were also compared in regard to the outcome of IVF-ET.
RESULTS
The total amount and duration of rhFSH administration were significantly higher in PCOS women with BMI > or =23 kg/m2 than in those with BMI <23 kg/m2 (P<0.001 in both). The implantation rate was significantly lower in women with BMI > or =23 kg/m2 (17.4% vs 7.8%, P=0.024). When compared three group divided on the basis of BMI <23 kg/m2 vs BMI 23~25 kg/m2 vs BMI > or =25 kg/m2, similar results were showed in women with BMI > or =25 kg/m2, although implantation rate in women with BMI > or =25 kg/m2 was lower with borderline significance (P=0.069).
CONCLUSION
Obesity (BMI > or =23 kg/m2) has a detrimental effect on implantation rate and is associated with the increased total amount and duration of rhFSH administration for ovarian stimulation in IVF-ET cycle. Consequently BMI may be a predictor for IVF outcomes in patients with PCOS.